This study will assess the clinical efficacy and safety of fluorouracil implants regional chemotherapy during the surgical treatment for early-stage hepatocellular carcinoma.

Inclusion Criteria:

• Histological diagnosis of stage I hepatocellular carcinoma
• Child-Pugh class A, B
• Radical resection is feasible
• Patients with adequate renal, hepatic, and hematologic function
• Written informed consent

Exclusion Criteria:

• Allergic to chemotherapy drugs
• No measurable lesion
• Receive chemotherapy, radiotherapy or biotherapy within 30 days prior to enrollment
• Evidence of serious infection
• Renal or hepatic dysfunction, significant cardiovascular disease
• Pregnant or lactating women