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| ID | Type | Description | Link |
|---|---|---|---|
| DBL-CHRD |
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This randomised, controlled, double-blinded clinical study investigates the safety and efficacy of albendazole (ALB), mebendazole (MBD) and ivermectin (IVM) separately, and ALB and MBD each in combination with IVM in the treatment of Trichuris trichiura in children aged 5-14 years.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Placebo Comparator | albendazole treatment |
|
| 2 | Active Comparator | mebendazole treatment |
|
| 3 | Active Comparator | ivermectin treatment |
|
| 4 | Active Comparator | albendazole + ivermectin treatment |
|
| 5 | Active Comparator | mebendazole + ivermectin treatment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| albendazole | Drug | albendazole (400 mg on dose) |
| |
| mebendazole |
| Measure | Description | Time Frame |
|---|---|---|
| Record adverse reactions | 6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Efficacy of treatment | 6 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Vector Control Division | Kampala | Uganda |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21885077 | Derived | Namwanje H, Kabatereine NB, Olsen A. Efficacy of single and double doses of albendazole and mebendazole alone and in combination in the treatment of Trichuris trichiura in school-age children in Uganda. Trans R Soc Trop Med Hyg. 2011 Oct;105(10):586-90. doi: 10.1016/j.trstmh.2011.07.009. Epub 2011 Aug 31. |
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| ID | Term |
|---|---|
| D010272 | Parasitic Diseases |
| ID | Term |
|---|---|
| D007239 | Infections |
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| ID | Term |
|---|---|
| D015766 | Albendazole |
| D008463 | Mebendazole |
| D007559 | Ivermectin |
| ID | Term |
|---|---|
| D002219 | Carbamates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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| Drug |
mebendazole (500 mg one dose) |
|
| ivermectin | Drug | ivermectin (200 microgram/kg body weight) |
|
| albendazole + ivermectin | Drug | albendazole (400 mg one dose) + ivermectin (200 mg microgram/kg body weight) |
|
| mebendazole + ivermectin | Drug | mebendazole (500 mg one dose) + ivermectin (200 microgram/kg body weight) |
|
| D001562 |
| Benzimidazoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D018942 | Macrolides |
| D061065 | Polyketides |
| D007783 | Lactones |