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| Name | Class |
|---|---|
| Sykehuset Asker og Baerum | OTHER |
| Diakonhjemmet Hospital | OTHER |
| Sykehuset Ostfold | OTHER |
| Haukeland University Hospital |
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The purpose of this study is to determine whether laparoscopic lavage changes the rate of severe complications in patients with acute perforated diverticulitis who traditionally are treated with primary resection.
Acute diverticulitis is a common disease in the western world. Perforation of the acute diverticulitis with peritonitis is a feared complication and standard treatment (primary sigmoid resection such as Hartmann's procedure) still has unsatisfactory results. Both mortality and morbidity are quite high. Several uncontrolled trials have reported a lower mortality and morbidity when acute perforated diverticulitis is treated with laparoscopic lavage instead of radical surgery. The investigators wish to conduct a randomized multicenter trial in Scandinavia in order to compare the rates of severe postoperative complications in acute perforated diverticulitis if treated by traditional primary sigmoid resection or by laparoscopic lavage. The investigators are planning to include all patients admitted to the participating hospitals with clinical and radiological findings of acute perforated diverticulitis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Laparoscopic lavage | Active Comparator |
| |
| Primary resection | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Surgery for acute perforated diverticulitis | Procedure | Primary resection vs laparoscopic lavage |
|
| Measure | Description | Time Frame |
|---|---|---|
| 90 days complication rate | 90 days |
| Measure | Description | Time Frame |
|---|---|---|
| Quality of life | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Tom Oresland, M.D., Ph.D. | University Hospital, Akershus | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Akershus University Hospital | Lorenskog | 1478 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33355658 | Derived | Azhar N, Johanssen A, Sundstrom T, Folkesson J, Wallon C, Korner H, Blecic L, Forsmo HM, Oresland T, Yaqub S, Buchwald P, Schultz JK; SCANDIV Study Group. Laparoscopic Lavage vs Primary Resection for Acute Perforated Diverticulitis: Long-term Outcomes From the Scandinavian Diverticulitis (SCANDIV) Randomized Clinical Trial. JAMA Surg. 2021 Feb 1;156(2):121-127. doi: 10.1001/jamasurg.2020.5618. | |
| 28631827 |
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| ID | Term |
|---|---|
| D004238 | Diverticulitis |
| ID | Term |
|---|---|
| D000076385 | Diverticular Diseases |
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
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| ID | Term |
|---|---|
| D013514 | Surgical Procedures, Operative |
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| OTHER |
| Sykehuset Innlandet HF | OTHER |
| Karolinska University Hospital | OTHER |
| University Hospital, Linkoeping | OTHER |
| Helse Nord-Trøndelag HF | OTHER |
| Skane University Hospital | OTHER |
| Helse Nordmøre og Romsdal | UNKNOWN |
| Ullevaal University Hospital | OTHER |
| Helse Stavanger HF | OTHER_GOV |
| Helse Nord | INDUSTRY |
| Uppsala University Hospital | OTHER |
| Centrallasarettet Västerås | OTHER |
| Sykehuset Buskerud HF | OTHER |
| Helsingborgs Hospital | OTHER |
| Vrinnevisjukhuset i Norrköping | UNKNOWN |
| Eskilstuna Lasarettet | OTHER |
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| Derived |
| Schultz JK, Wallon C, Blecic L, Forsmo HM, Folkesson J, Buchwald P, Korner H, Dahl FA, Oresland T, Yaqub S; SCANDIV Study Group. One-year results of the SCANDIV randomized clinical trial of laparoscopic lavage versus primary resection for acute perforated diverticulitis. Br J Surg. 2017 Sep;104(10):1382-1392. doi: 10.1002/bjs.10567. Epub 2017 Jun 20. |
| 26441181 | Derived | Schultz JK, Yaqub S, Wallon C, Blecic L, Forsmo HM, Folkesson J, Buchwald P, Korner H, Dahl FA, Oresland T; SCANDIV Study Group. Laparoscopic Lavage vs Primary Resection for Acute Perforated Diverticulitis: The SCANDIV Randomized Clinical Trial. JAMA. 2015 Oct 6;314(13):1364-75. doi: 10.1001/jama.2015.12076. |