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| Name | Class |
|---|---|
| The German Heart Foundation | OTHER |
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"Atherosclerosis is an inflammatory disease". The hypothesis of an infectious burden as trigger or initiator of the inflammatory process in atherosclerosis has been extensively discussed in the past years. One part of this discussion is focused on the infectious agents responsible for periodontitis. Several studies have found an association of periodontitis and/or bacteria related to this disease and atherosclerosis. However, a study focussing on the prognostic relevance of these factors is missing.
The hypothesis of this study is that periodontitis is a prognostic relevant risk factor for patients with angiographically proven coronary heart disease. Furthermore, the infectious pathogen burden by PCR-detection of periodontal pathogens will be evaluated as a prognostic factor.
960 consecutive patients with angiographically proven coronary heart disease will be included in this study. After inclusion of patients an extensive periodontal examination including PCR-sampling for 11 bacteria (Porphyromonas gingivitis, Actinobacillus actinomycetemcomitans, and others) will be performed. After 12 months patient will be follow up for any major adverse events (cardiovascular death, myocardial infarction, stroke).
If this study will find a relation of periodontitis or its microbiological agents to cardiovascular outcome of patients with coronary heart disease, further studies are necessary to investigate potential therapeutic consequences for patients with CHD and periodontitis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| coronary heart disease |
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| Measure | Description | Time Frame |
|---|---|---|
| Combined endpoint: myocardial infarction, cardiovascular death, stroke | 12 months follow-up |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with coronary heart disease, admitted to the Martin Luther-University Halle-Wittenberg
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| Name | Affiliation | Role |
|---|---|---|
| Axel Schlitt, MD | Department of Medicine III, Martin Luther-University Halle-Wittenberg | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Martin Luther-University Halle-Wittenberg | Halle | 06097 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41789954 | Derived | Reichert S, Schlitt A, Rehm S, Schulz S. Impact of severe periodontitis and diabetes mellitus on recurrent cardiovascular outcomes. J Periodontol. 2026 Jun;97(6):1360-1371. doi: 10.1002/jper.70086. Epub 2026 Mar 6. | |
| 39578376 | Derived | Reichert S, Rehm S, Schlitt A, Schulz S. Severe Periodontitis is Associated With Recurrent Cardiovascular Events-A 10-Year Longitudinal Cohort Study. J Periodontal Res. 2025 Dec;60(12):1201-1211. doi: 10.1111/jre.13365. Epub 2024 Nov 22. |
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| ID | Term |
|---|---|
| D010518 | Periodontitis |
| D003327 | Coronary Disease |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D017202 | Myocardial Ischemia |
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Blood-samples and samples from gingival pockets
| 39199367 | Derived | Schulz S, Reuter L, Navarrete Santos A, Bitter K, Rehm S, Schlitt A, Reichert S. Major Adverse Cardiovascular Events: The Importance of Serum Levels and Haplotypes of the Anti-Inflammatory Cytokine Interleukin 10. Biomolecules. 2024 Aug 9;14(8):979. doi: 10.3390/biom14080979. |
| 38067150 | Derived | Schulz S, Rehm S, Schlitt A, Bitter K, Reichert S. The Interleukin 6 Protein Level as well as a Genetic Variants, (rs1800795, rs1800797) Are Associated with Adverse Cardiovascular Outcomes within 10-Years Follow-Up. Cells. 2023 Nov 28;12(23):2722. doi: 10.3390/cells12232722. |
| 37443809 | Derived | Schulz S, Rehm S, Schlitt A, Lierath M, Ludike H, Hofmann B, Bitter K, Reichert S. C-Reactive Protein Level and the Genetic Variant rs1130864 in the CRP Gene as Prognostic Factors for 10-Year Cardiovascular Outcome. Cells. 2023 Jul 4;12(13):1775. doi: 10.3390/cells12131775. |
| 34305452 | Derived | Schulz S, Zielske M, Schneider S, Hofmann B, Schaller HG, Schlitt A, Reichert S. Polymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease. Mediators Inflamm. 2021 Jul 8;2021:3002439. doi: 10.1155/2021/3002439. eCollection 2021. |
| 31770616 | Derived | Reichert S, Seitter L, Schaller HG, Schlitt A, Schulz S. ANRIL polymorphisms (rs1333049 and rs3217992) in relation to plasma CRP levels among in-patients with CHD. Cytokine. 2020 Mar;127:154932. doi: 10.1016/j.cyto.2019.154932. Epub 2019 Nov 27. |
| 31765020 | Derived | Schulz S, Schlitt A, Hofmann B, Schaller HG, Reichert S. Periodontal pathogens and their role in cardiovascular outcome. J Clin Periodontol. 2020 Feb;47(2):173-181. doi: 10.1111/jcpe.13224. Epub 2019 Dec 16. |
| 27570807 | Derived | Reichert S, Schlitt A, Benten AC, Hofmann B, Schaller HG, Schulz S. Data on IL-6 c.-174 G>C genotype and allele frequencies in patients with coronary heart disease in dependence of cardiovascular outcome. Data Brief. 2016 Jul 16;8:1295-9. doi: 10.1016/j.dib.2016.07.020. eCollection 2016 Sep. |
| 22691114 | Derived | Schulz S, Schlitt A, Lutze A, Lischewski S, Seifert T, Dudakliewa T, Gawe R, Werdan K, Hofmann B, Glaser C, Schaller HG, Reichert S. The importance of genetic variants in TNFalpha for periodontal disease in a cohort of coronary patients. J Clin Periodontol. 2012 Aug;39(8):699-706. doi: 10.1111/j.1600-051X.2012.01909.x. Epub 2012 Jun 12. |
| D006331 |
| Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |