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The purpose of this study is to determine if cognitive impairment induced by scopolamine is reversed using donepezil and/or AZD1446 as compared to placebo, as assessed by electroencephalogram (EEG) measures.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| A | Experimental | Single dose of AZD1446 10 mg |
|
| B | Experimental | Single dose of AZD1446 80 mg |
|
| C | Active Comparator | Single Dose of Donepezil 5 mg |
|
| D | Placebo Comparator | Single dose of placebo to match AZD1446 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| AZD1446 | Drug | capsule; single oral dose |
| |
| AZD1446 |
| Measure | Description | Time Frame |
|---|---|---|
| qEEG assessed through the absolutes alpha-power of the two occipital leads | In each treatment period (1, 2, 3, 4) the measure will be taken on Day 1 prior to dosing of AZD1446 or placebo and1h, 2h, 3h, 6h, and 24 hour after dosing of AZD1446 or placebo |
| Measure | Description | Time Frame |
|---|---|---|
| qEEGs/ERPs assessed by mismatch negativity and p300 | In each treatment period (1, 2, 3, 4) the measure will be taken on Day 1 prior to dosing of AZD1446 or placebo and1h, 2h, 3h, 6h, and 24 hour after dosing of AZD1446 or placebo |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research Site | Rouffach | France |
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| ID | Term |
|---|---|
| C578484 | 3-(5-chloro-2-furoyl)-3,7-diazabicyclo(3.3.0)octane |
| D000077265 | Donepezil |
| ID | Term |
|---|---|
| D007189 | Indans |
| D007192 | Indenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D006841 | Hydrocarbons, Aromatic |
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| Drug |
capsule, single oral dose |
|
| donepezil | Drug | capsule, single oral dose |
|
|
| Placebo | Drug | capsule, single oral dose |
|
| D006844 |
| Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D011083 | Polycyclic Compounds |