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| Name | Class |
|---|---|
| University of Copenhagen | OTHER |
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The purpose of this study is to evaluate the impact of different ligands of GPR 119 (a G protein-coupled receptor in the intestine) on the secretion of the incretin hormones, GLP-1 and GIP.
We have found a new ligand for the GPR 119 receptor. This study evaluate the impact of this ligand on the incretion hormone responses, beta cell function and gall bladder function in healthy young men.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GPR119 agonist, 2-oleoyl glycerol | Experimental | 2-oleoyl glycerol; 2g. and vehicle |
|
| Oleic acid | Active Comparator | oleic acid; 3.2g and vehicle |
|
| Vehicle | Placebo Comparator | 5 ml. of glycerol and 5 ml 96% ethanol |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| GPR 119 agonist, 2-oleyl glycerol | Dietary Supplement | Emulgation, 50 ml. containing 2g 2OG |
|
| Measure | Description | Time Frame |
|---|---|---|
| The effect of this newly discovered GPR 119 agonist on gut hormone responses, in particular GLP-1 in response of the different meals administered to the subjects | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Glucose homeostasis, gall bladder contraction in response of the different meals administered to the subjects | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Katrine B Hansen, MD | Glostrup Hospital, University of Copenhagen | Principal Investigator |
| Filip K Knop, MD, Ph.d | Gentofte Hospital | Study Director |
| Harald S Hansen, professor | Farmaceutical Faculty, University of Copenhagen | Study Director |
| Jens J Holst, MD;DMSc | Biomedical Science, University of Copenhagen | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Clinical Physiology, Glostrup Hospital | Glostrup Municipality | 2600 | Denmark |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D019301 | Oleic Acid |
| ID | Term |
|---|---|
| D009829 | Oleic Acids |
| D005229 | Fatty Acids, Monounsaturated |
| D005231 | Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
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| Oleic acid | Dietary Supplement | Emulgation, 50 ml. containing 1.54g of oleic acid |
|
| Vehicle | Dietary Supplement | Fifty milliliters of glycerol (Sigma-Aldrich; batch 32296AK, purity 99%) plus 5 ml 96% ethanol |
|
| D004700 | Endocrine System Diseases |
| D008055 |
| Lipids |