Drug-Drug Interaction Study With Aricept® (Donepezil)

A Study of the Effect of Concomitant Administration of BMS-708163 on the Pharmacokinetics of Donepezil in Healthy Subjects

The purpose of this study is to find out if the plasma concentration of donepezil is changed when BMS-708163 is administered at the same time

Inclusion Criteria:

• Healthy men and postmenopausal women

Exclusion Criteria:

• Medical History and Concurrent Diseases
• Gastrointestinal disease
• Gastrointestinal bleeding disorders
• History of peptic ulcer disease
• History of cholecystectomy
• History of seizure disorder
• History of asthma
• History of Chronic Obstructive Pulmonary Disease
• History of cardiac conduction abnormalities, including but not limited to "sick sinus syndrome" and those with unexplained syncopal episodes
• Inability to tolerate oral medication
• Inability to be venipunctured and/or tolerate venous access