Long-term Pleiotropic Effect of Statins in Patients With Peripheral Arterial Disease

Phase IV Study of Statins for Assess the Long-term Pleiotropic Effect Upon Nitric Oxide and C-Reactive Protein Levels in Patients With Peripheral Arterial Disease

The purpose of this study is to determine the long-term effects of statins, atorvastatin, upon Nitric Oxide, as an endothelial function assessment, and C-Reactive Protein, an inflammatory marker, levels in patients with Peripheral Arterial Disease. These long-term biological pleiotropic effects of statins will offer information on the role of endothelial function and systemic inflammation in the etiopathogenesis of PAD.

Inclusion Criteria:

• patients at the time of diagnosis of Fontaine grade II peripheral arterial disease (PAD), confirmed by hemodynamic evaluation (Doppler ultrasound)
• over 18 years old

Exclusion Criteria:

• patients had previously undergone revascularization
• patients were receiving treatment with statins
• patients with contraindications to statin use.
• patients with coexistence of chronic inflammatory diseases or steroidal medication