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| ID | Type | Description | Link |
|---|---|---|---|
| RJH-2009 | Other Identifier | RuiJin Hospital, Shanghai Jiaotong University School of Medicine |
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PCI has been one of the most common choice of treatments for patients with coronary artery disease, and studies indicated that intensive statin treatment before PCI could reduce adverse events as comparing to the placebo. In China, statin with regular dose is currently applied to the patients admitted for Non-ST-elevation acute coronary syndrome (ACS). Here we hypothesize that intensive statin treatment with arovastatin before PCI could further reduce clinical adverse events.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| conventional group | Active Comparator | patients will be treated by atorvastation 20mg/d after randomization, and continued for one year. |
|
| intensive group | Experimental | patient will be loaded with 80mg atorvastatin, continued by atorvastatin 40mg/d for 30d, then receive atorvastatin 20mg/d for the following 11 months. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Atorvastatin | Drug | patients admitted for Non-ST elevation ACS will be treated by atorvastatin 20md/d for one year |
|
| Measure | Description | Time Frame |
|---|---|---|
| The primary end point was the composite of major adverse cardiac events (MACE), including cardiac death, non-fatal reinfarction, and target vessel revascularization (TVR) at one-year clinical follow-up after randomization. | one year |
| Measure | Description | Time Frame |
|---|---|---|
| rate of peri-procedural myocardial infarction | 30days | |
| MACE at 30d after randomization 3. changes of left ventricular function at 30d after randomization | 30 days | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Qi Zhang, MD | Contact | +862164370045 | 665380 | zhangqnh@yahoo.com |
| Xin Chen, MD | Contact | +862164370045 | 665215 | rjchenxin@yahoo.com.cn |
| Name | Affiliation | Role |
|---|---|---|
| Wei Feng Shen, MD, PhD | Shanghai Jiao Tong University School of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ruijin Hospital, Dept. of Cardiology | Recruiting | Shanghai | Shanghai Municipality | 200025 | China |
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| ID | Term |
|---|---|
| D054058 | Acute Coronary Syndrome |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D000069059 | Atorvastatin |
| ID | Term |
|---|---|
| D011758 | Pyrroles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Atorvastatin | Drug | patients admitted with Non-ST elevation ACS will be loaded with atorvastatin 80mg once, continued with 40mg/d for 30d, then change to 20mg/d, as a regular dose in China |
|
| changes of left ventricular function at 30d after randomization |
| 30 days |
| D006538 |
| Heptanoic Acids |
| D005227 | Fatty Acids |
| D008055 | Lipids |