The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of TD-1211 in healthy subjects and activity in subjects with opioid-induced constipation (OIC).

Inclusion Criteria:

• Males and females between 18 and 65 years of age, inclusive
• Healthy subjects and subjects with documented OIC on stable opioid regimen
• Willingness to stop all laxatives throughout the OIC screening and treatment period

Exclusion Criteria:

• Any clinically significant finding in healthy subjects
• Have participated in another clinical trial of an investigational drug 30 days prior to screening
• History of chronic constipation prior to opioid therapy in OIC subjects
• Active medical disorders associated with diarrhea or intermittent loose stools in OIC subjects