Gut Oxygenation and Laparoscopy

GUT OXYGENATION DURING AND AFTER LAPAROSCOPIC AND OPEN COLON RESECTION. A RANDOMIZAD CLINICAL TRIAL

Patients with left-colon cancer will be randomized to laparoscopic or laparotomic operation. during surgery and for 6 days after operation, intestinal oxygen tension and ischemia-reperfusion injury markers will be evaluated to understand if pneumoperitoneum is associated with reduced splanchnic blood flow and ischemia-reperfusion injury.

Inclusion Criteria:

• Proven Cleft Colon Cancer, Signed Informed Consent

Exclusion Criteria:

• Emergency surgery,
• Cancer infiltrating adjacent organ (at CT scan),
• Severe cardiovascular (New York Heart Association class > 3 ),
• Respiratory (arterial PO2 < 70 mmHg),
• Renal (plasma creatinine > 3 MG/dL) or hepatic (Child C) dysfunction