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| Name | Class |
|---|---|
| The Danish Medical Research Council | OTHER |
| The Novo Nordic Foundation | OTHER |
| The Danish Diabetes Association | OTHER |
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Type 2 diabetes is associated with diabetic dyslipidemia, which is a major risk factor for coronary heart disease. Triglycerides (TG) and cholesterol are transported in the system of lipoproteins, and the metabolism of these lipids in plasma is closely interrelated. Evidence suggests that increased concentration of very low-density lipoprotein triglyceride (VLDL-TG) is a central pathophysiological feature of the lipid and lipoprotein abnormalities in diabetic dyslipidemia.
The objective of this study was to investigate VLDL-TG kinetics and aspects of peripheral VLDL-TG metabolism, i.e. to what extent VLDL-TG associated fatty acids (FA) are oxidized or deposited in regional adipose tissue, in subjects with type 2 diabetes and healthy controls in the postabsorptive state and during acute hyperinsulinemia using ex-vivo labeled VLDL-TG tracers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Type 2 diabetic men | Men with type 2 diabetes |
| |
| Healthy men | Healthy men |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hyperinsulinemic euglycemic glucose clamp | Other | Hyperinsulinemic euglycemic glucose clamp, duration 5 hours, plasma glucose 5 mmol/l, insulin dosage 1,0 mU•kg FFM/min, human insulin (Actrapid; Novo Nordisk A/S). |
| Measure | Description | Time Frame |
|---|---|---|
| VLDL-TG production and clearance rates |
| Measure | Description | Time Frame |
|---|---|---|
| VLDL-TG oxidation | ||
| VLDL-TG subcutaneous adipose tissue storage |
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Inclusion Criteria:
Exclusion Criteria:
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11 men with type diabetes and 11 healthy men, matched for age and BMI.
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| Name | Affiliation | Role |
|---|---|---|
| Søren Nielsen, DMSc | Medical department M (Endocrinology and Diabetes), Aarhus University Hospital, Denmark | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical department M (Endocrinology and Diabetes), Aarhus University Hospital | Aarhus | DK | 8000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27898284 | Derived | Andersen IR, Sondergaard E, Sorensen LP, Nellemann B, Gormsen LC, Jensen MD, Nielsen S. Increased VLDL-TG Fatty Acid Storage in Skeletal Muscle in Men With Type 2 Diabetes. J Clin Endocrinol Metab. 2017 Mar 1;102(3):831-839. doi: 10.1210/jc.2016-2979. | |
| 20858686 | Derived | Sorensen LP, Andersen IR, Sondergaard E, Gormsen LC, Schmitz O, Christiansen JS, Nielsen S. Basal and insulin mediated VLDL-triglyceride kinetics in type 2 diabetic men. Diabetes. 2011 Jan;60(1):88-96. doi: 10.2337/db10-0564. Epub 2010 Sep 21. |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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Blood samples Subcutaneous adipose tissue biopsies Muscle biopsies
| D004700 | Endocrine System Diseases |