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In heart failure patients we hypothesised that right ventricular high posterior septum is superior to right ventricular apex in CRT and DDD pacemaker. In two separate trials we prospectively randomized the right ventricular lead placement to find evidence of differences in heart failure symptoms (NYHA-class), 6 minute hall walk and echocardiographic measurements of reverse remodelling and dyssynchrony.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CRT; RV apical lead placement | Active Comparator | Right ventricular apical lead placement in CRT |
|
| CRT; RV high posterior septum | Active Comparator | High posterior septal lead placement in CRT |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CRT in heart failure; Right ventricular apex v.s. high posterior septum | Device | RV lead is randomized to either apex or high posterior septum |
|
| Measure | Description | Time Frame |
|---|---|---|
| Echocardiographic reverse remodelling and dyssynchrony | 3, 6, 12, 18 and 24 months |
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Inclusion Criteria:
CRT:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Svein Faerestrand, MD, PhD | Faerestrand S | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Haukeland University Hospital | Bergen | 5021 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22677455 | Derived | Kristiansen HM, Vollan G, Hovstad T, Keilegavlen H, Faerestrand S. The impact of left ventricular lead position on left ventricular reverse remodelling and improvement in mechanical dyssynchrony in cardiac resynchronization therapy. Eur Heart J Cardiovasc Imaging. 2012 Dec;13(12):991-1000. doi: 10.1093/ehjci/jes114. Epub 2012 Jun 7. | |
| 22308084 |
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| CRT in heart failure; Right ventricular apex v.s. high posterior septum | Device | RV lead is randomized to either apex or high posterior septum |
|
| Kristiansen HM, Hovstad T, Vollan G, Keilegavlen H, Faerestrand S. Clinical implication of right ventricular to left ventricular interlead sensed electrical delay in cardiac resynchronization therapy. Europace. 2012 Jul;14(7):986-93. doi: 10.1093/europace/eur429. Epub 2012 Feb 2. |
| 22286156 | Derived | Kristiansen HM, Vollan G, Hovstad T, Keilegavlen H, Faerestrand S. A randomized study of haemodynamic effects and left ventricular dyssynchrony in right ventricular apical vs. high posterior septal pacing in cardiac resynchronization therapy. Eur J Heart Fail. 2012 May;14(5):506-16. doi: 10.1093/eurjhf/hfr162. Epub 2012 Jan 26. |
| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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