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Study hypothesis:- Benign joint hyper mobility syndrome which persists into adulthood is a special type of benign joint hyper mobility which is more likely to predispose to chronic musculoskeletal pain.
Young Indian adults aged between 25 and 40 years who are blood donors or relatives of patients admitted as inpatient or presenting to the out patient department, in Amrita Institute of Medical Sciences will be enrolled, after excluding the exclusionary criteria. They will be assessed for the presence of chronic musculoskeletal pain using a validated self filled questionnaire. The primary investigator who will be blinded to their response will examine them for the presence of Benign Joint Hyper mobility Syndrome and for tender points suggestive of fibromyalgia.
Primary Objective:- To determine whether chronic musculoskeletal pain is associated with Hypermobility among Indian adults.
Study design:- Cross sectional survey
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Young healthy Indian adults | Persons aged between 25 and 40 years of age who are relatives of patients being treated in Amrita Institute of Medical Sciences (Inpatient or Outpatient) and voluntary blood donors at the same institute who are willing to participate in the study. |
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| Measure | Description | Time Frame |
|---|---|---|
| To determine whether chronic musculoskeletal pain is associated with hypermobility among young Indian adults | 3-6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Determine whether hypermobility is associated with the presence of fibromyalgia in young Indian adults. | 3-6 months | |
| Determine the prevalence of hypermobility among Indian adults | 3-6 months | |
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Inclusion Criteria:
Exclusion Criteria:
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Young Indian adults aged between 25 years and 40 years
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| Name | Affiliation | Role |
|---|---|---|
| Sharath Kumar, MD | Amrita Institute of Medical Sciences | Principal Investigator |
| L Rajam, MD | Amrita Institute of Medical Sciences | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Amrita Institute of Medical Sciences | Kochi | Kerala | 682041 | India |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19465584 | Background | Leone V, Tornese G, Zerial M, Locatelli C, Ciambra R, Bensa M, Pocecco M. Joint hypermobility and its relationship to musculoskeletal pain in schoolchildren: a cross-sectional study. Arch Dis Child. 2009 Aug;94(8):627-32. doi: 10.1136/adc.2008.150839. Epub 2009 May 12. | |
| 8923376 | Background | Mikkelsson M, Salminen JJ, Kautiainen H. Joint hypermobility is not a contributing factor to musculoskeletal pain in pre-adolescents. J Rheumatol. 1996 Nov;23(11):1963-7. |
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| ID | Term |
|---|---|
| D007593 | Joint Instability |
| D018771 | Arthralgia |
| D009209 | Myofascial Pain Syndromes |
| D005356 | Fibromyalgia |
| D013001 | Somatoform Disorders |
| ID | Term |
|---|---|
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
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| Determine prevalence of fibromyalgia in young Indian adults |
| 3-6 months |
| Determine the prevalence of chronic musculoskeletal pain among young indian adults | 3-6 months |
| Determine the association between American College of Rheumatology criteria for definition of Fibromyalgia and Simplified intensity scale questionnaire definition of Fibromyalgia. | 3-6 months |
| 12612280 | Background | Engelbert RH, Bank RA, Sakkers RJ, Helders PJ, Beemer FA, Uiterwaal CS. Pediatric generalized joint hypermobility with and without musculoskeletal complaints: a localized or systemic disorder? Pediatrics. 2003 Mar;111(3):e248-54. doi: 10.1542/peds.111.3.e248. |
| 16636935 | Background | Sendur OF, Gurer G, Bozbas GT. The frequency of hypermobility and its relationship with clinical findings of fibromyalgia patients. Clin Rheumatol. 2007 Apr;26(4):485-7. doi: 10.1007/s10067-006-0304-4. Epub 2006 Apr 25. |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009135 | Muscular Diseases |
| D012216 | Rheumatic Diseases |
| D009468 | Neuromuscular Diseases |
| D009422 | Nervous System Diseases |
| D001523 | Mental Disorders |