Study To Assess Changes In The Number Of Nerves In The Skin At The Site Where Where Tanezumab Is Injected

A Phase 1, Randomized, Double- Blind (Sponsor-Open), Placebo-Controlled Study To Examine The Density Of Intraepidermal Nerve Fibers After A Single Subcutaneous Administration Of Tanezumab In Healthy Volunteers

Subcutaneous administration of tanezumab can result in changes in the number of nerves around the injection site in the thigh.

Inclusion Criteria:

• Healthy subjects only
• Female subjects can not be pregnant or be nursing.
• Females and males need to use two types of birth control methods during the length of the study and one of the two methods needs to be a barrier method.
• Subjects who are willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures.

Exclusion Criteria:

• Subject can not have any chronic or acute medical condition or have had any chronic illness in the past
• Can not have any problematic skin condition.
• Females can not have more than 7 alcoholic drinks per week and males can not have more than 14 alcoholic drinks per week