A Trial Comparing Yield of Confocal Endomicroscopy Guided Biopsies

A Prospective Randomized Trial Comparing Yield of Confocal Endomicroscopy Guided Biopsies With Random Biopsies in the Detection of Specialized Columnar Epithelium in Barrett's Esophagus

We wish to determine whether biopsies obtained with the technique of fluorescence-aided confocal endomicroscopy will detect more patients with specialized columnar epithelium than random biopsies among patients with Barrett's esophagus who are being monitored with endoscopy.

Inclusion Criteria:

• Age at least 18.
• Barrett's esophagus
• Acid suppressive therapy
• Endoscopic surveillance

Exclusion Criteria:

• Pregnancy or lactation
• Allergy to fluorescein
• Endoscopic esophagitis Los Angeles classification A to D
• Mucosal irregularity or nodules suspicious for dysplastic or cancerous lesion
• Obvious mass lesions or cancer