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This is a first in human study which will assess the safety and tolerability of a monoclonal antibody against ICAM-1 in patients with Multiple Myeloma. The tumour response rate will also be measured.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| BI-505 | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| BI-505 | Biological | Anti-ICAM-1 monoclonal antibody given as a i.v infusion every second week for four weeks, |
|
| Measure | Description | Time Frame |
|---|---|---|
| Safety assessed as Adverse Events, ECG, vital signs and clinical laboratory tests | four weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Guido Tricot, MD, PhD, Prof. | University of Utah | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Maryland, Greenebaum Cancer Center | Baltimore | Maryland | 21201 | United States | ||
| University of Utah Health Sciences Center, Department of Medicine, Division of Hematology, Utah Blood and Marrow Transplant and Myeloma Program |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25712687 | Derived | Hansson M, Gimsing P, Badros A, Niskanen TM, Nahi H, Offner F, Salomo M, Sonesson E, Mau-Sorensen M, Stenberg Y, Sundberg A, Teige I, Van Droogenbroeck J, Wichert S, Zangari M, Frendeus B, Korsgren M, Poelman M, Tricot G. A Phase I Dose-Escalation Study of Antibody BI-505 in Relapsed/Refractory Multiple Myeloma. Clin Cancer Res. 2015 Jun 15;21(12):2730-6. doi: 10.1158/1078-0432.CCR-14-3090. Epub 2015 Feb 24. |
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| ID | Term |
|---|---|
| D009101 | Multiple Myeloma |
| ID | Term |
|---|---|
| D054219 | Neoplasms, Plasma Cell |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D020141 | Hemostatic Disorders |
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| Salt Lake City |
| Utah |
| 84132-2408 |
| United States |
| AZ Sint-Jan | Bruges | 8000 | Belgium |
| Ghent University Hospital | Ghent | 9000 | Belgium |
| Rigshospitalet | Copenhagen | 2100 | Denmark |
| Karolinska University Hospital | Huddinge | 141 86 | Sweden |
| Hematology Clinic Cancer Division, Skåne University Hospital | Lund | SE-22185 | Sweden |
| D014652 |
| Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D010265 | Paraproteinemias |
| D001796 | Blood Protein Disorders |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D006474 | Hemorrhagic Disorders |
| D008232 | Lymphoproliferative Disorders |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |