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| ID | Type | Description | Link |
|---|---|---|---|
| A080587 | Other Grant/Funding Number | Korea Healthcare Technology R&D Project |
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| Name | Class |
|---|---|
| Korea Healthcare Technology R&D Project | UNKNOWN |
| Korea Advanced Institute of Science and Technology | OTHER |
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A single-nucleotide polymorphism (SNP) analysis of DNA obtained from peripheral blood of the glaucoma patients and the normal control will be performed to find genetic marker for primary open angle glaucoma.
Unrelated Korean subjects who have primary open angle glaucoma were recruited in the current study. Genotyping for various SNP associated with POAG due to the linkage disequilibrium patterns is to be performed. Genotypes would be statistically compared between patients with primary open angle glaucoma and normal control subjects free of any eye diseases.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| POAG group | Elevated intraocular pressure normal open angle glaucomatous optic nerve head abnormality glaucomatous visual field defect |
| |
| Normal control | Normal intraocular pressure No optic disc abnormality No visual field defect No significant ocular and systemic disease |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SNP analysis of the DNA | Genetic | SNP analysis of the DNA obtained from peripheral blood sample |
|
| Measure | Description | Time Frame |
|---|---|---|
| genotyping for the SNP associated with primary open angle glaucoma | one year |
| Measure | Description | Time Frame |
|---|---|---|
| genotyping for rs7961953 and additional SNPs in TMTC2 from other linkage disequilibrium patterns | one year |
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Inclusion Criteria:
Exclusion Criteria:
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patients with open angle glaucoma who visited glaocoma clinic of departemtn of Ophtalmology, Chungnam National University Hospital, Daejeon, south Korea
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| Name | Affiliation | Role |
|---|---|---|
| Chang-sik Kim, professor | Department of Ophthalmology, Chungnam National University Hospital | Principal Investigator |
| Changwon Kang, professor | Korea Advanced Institute of Science and Technology | Study Chair |
| Kyunglan Kim | Department of Biological Sciences, Korea Advanced Institute of Science and Technology | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chungnam National University Hospital | Daejeon | 301-721 | South Korea |
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| ID | Term |
|---|---|
| D005901 | Glaucoma |
| D005902 | Glaucoma, Open-Angle |
| ID | Term |
|---|---|
| D009798 | Ocular Hypertension |
| D005128 | Eye Diseases |
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Peripheral blood sample