Clinical Validation of a Microfluidic Device for Isolation and Molecular Characterization of Circulating Tumor Cells

Clinical Validation of a Microfluidic Device for Isolation and Molecular Characterization of Circulating Tumor Cells

To evaluate the efficiency of a microdevice for circulating tumor cells isolation and to correlate the circulating titre with response and progression.

• Validate the clinical use of a mircofluidic device to capture circulating timor cells from a broad range of tumor types
• Characterize and identify these circulating tumor cells and demostrate cell viability with this capture method
• Apply this technology in clinically relevant settings and correlate to response to treatment and disease progression
• Elucidate predictive and pharmacodynamic biomarkers in the context of early phase trials of novel therapeutics

Inclusion Criteria:

• Patients with newly diagnosed metastatic disease planned for palliative chemotherapy
• Tumor types as specified: non smokers with lung adenocarcinoma, undifferentiated EBV-ISH positive nasopharyneal carcinoma, breast cancer, colorectal cancer, prostate cancer, gastric cancer
• Informed consent given for the purposes of blood sampling for this study
• Measurable disease by RECIST criteria of at least 1cm is preferred but not a sine qua non for study accrual

Exclusion Criteria:

• N/A