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Fear of full stomach when emergency general anaesthesia is required is the origin of fastening when giving birth. This behaviour does not warranty perfect security for the general anaesthesia. In addition, well being for women and new born is affected. Giving birth is finally compared to a sportive competition with high-energy needs. As Intravenous energy intake is not regulated by physiologic digestion, it can induce metabolic disorders for the mother that can be amplified for the foetus.
Oral glucose drinks could offer some benefits:
However, it has never been shown yet that such behaviour could offer those benefits. Also, it seems that there is not more vomiting, but most of the studies compared oral glucose intake to waterborne intake with the same volumes The expected efficacy is a reduction in labour duration and a reduction in percentage of extraction. Previous studies said that the lack of statistical power due to small number of subjects caused the absence of statistical significant relationship.
In addition, even though newborn have less acidosis, there is no clinical relationship proven.
The investigators propose a randomised multicentre study to assess efficacy of oral glucose drinks in comparison to traditional fastening when giving birth.
Main objective is to significantly reduce instrumental extraction rates. 5400 women will be included in the study in 2 years.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| A | Active Comparator | Glucose drink |
|
| B | No Intervention | Fasting |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Glucose drink | Other | 200 mL each 3 hours up to 8 cm of dilatation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Instrumental extraction rates | During childbirth |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Thérèse SIMONET, MD | University Hospital, Caen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital, Avranches | Avranches | France | ||||
| Centre Hospitalier |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31702699 | Result | Simonet T, Gakuba C, Desmeulles I, Corouge J, Beucher G, Morello R, Gerard JL, Ducloy-Bouthors AS, Dreyfus M, Hanouz JL. Effect of Oral Carbohydrate Intake During Labor on the Rate of Instrumental Vaginal Delivery: A Multicenter, Randomized Controlled Trial. Anesth Analg. 2020 Jun;130(6):1670-1677. doi: 10.1213/ANE.0000000000004515. |
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| Bayeux |
| 14400 |
| France |
| Clinique du Parc | Caen | 14000 | France |
| University Hospital, Caen | Caen | 14033 | France |
| Centre Hospitalier du Rouvray | Elbeuf | 76350 | France |
| University Hospital, Lille | Lille | France |
| Hospital, Mont Saint Aignan | Mont-Saint-Aignan | France |
| University Hospital, Rouen | Rouen | France |
| Centre Hospitalier Mémorial France Etats-Unis | Saint-Lô | 50000 | France |