Comparison of Refined and Crude Indigo Naturalis Ointment in Treating Psoriasis

Efficacy and Safety Comparison Between Refined and Crude Indigo Naturalis Ointment in the Treatment of Psoriatic Vulgaris

To compare the efficacy and safety of refined indigo naturalis ointment with that of crude ointment in treating psoriasis.

Our previous studies have shown that topical application of indigo naturalis significantly improves psoriatic symptoms. However, patient compliance is hindered because the preparation is unsightly and stains clothing.

To improve patient compliance, we have developed a refined formulation in which closer to natural skin tones and less prone to stain clothing. In this study, we evaluated the efficacy and safety of this refined form of oil extract ointment and compared the results with those of the original crude form of indigo naturalis ointment in treating psoriasis.

Inclusion Criteria:

• Patients were had received a diagnosis of plaque psoriasis based on clinical assessment by two dermatologists at least a one year prior to entry into the study;
• Patients had mild to moderate plaque psoriasis with bilateral symmetric lesions; were adults aged 20 to 65 years;
• Patients were in good general health.
• Female patients of childbearing age agreed to continue using birth control measures for the duration of the study.

Exclusion Criteria:

• Patients had non-plaque (i.e., pustular, guttate, or erythrodermic) or drug-induced forms of psoriasis; total body surface involvement of more than 60%;
• Patients had a history of allergy to indigo naturalis.
• Patients were excluded if they have received systemic therapy within 4 weeks before enrollment, phototherapy within 3 weeks, or used topical psoriasis agents within 2 weeks before enrollment.
• Patients had included usage of medications that affect psoriasis during the study and unwillingness to comply with study protocol.