Study of the Causes of the Breakdown of Muscle Fibers in Hospitalized Patients

Rhabdomyolysis - A Retrospective Study in Hospitalized Patients

1. Analyze the various causes of breakdown of muscle fibers in hospitalized patients.
2. Analyze the characteristics of these patients in Taiwan (including the drugs history, risk factors and the incidence of complications).

1. Find the causes of breakdown of muscle fibers in hospitalized patients through medical record review.

   • especially drug-related

2. Find the risk factors of muscle fibers breakdown.

Inclusion Criteria:

• Patients who admitted to The National Taiwan University Hospital during 2003/1/1~2008/12/31 with the following discharge diagnosis: myoglobinuria, rhabdomyolysis, myopathy, toxic myopathy, malignant hyperthermia, neuroleptic malignant syndrome, polymyositis, myalgia and had acute neuromuscular illness presentations and serum creatinine kinase (CK) more than 5 times the upper limit of normal (male > 900 IU/L; female > 835 IU/L).

Exclusion Criteria:

• Patients with recent myocardial infarction or stroke, unless clinical history, examination, or electromyography showed a concomitant myopathy.