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| Name | Class |
|---|---|
| Tampere University | OTHER |
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The purpose of this study is to analyze how common stress hyperglycaemia (abnormally high blood glucose) is in primary hip and knee replacement surgeries and which factors predispose to hyperglycaemia.
Postoperative infections remain one of the most frequent reasons of failure of hip and knee prostheses. Diabetes increases the risk of infections. In other fields of surgery, hyperglycemia induced by surgical stress (stress/perioperative hyperglycemia) has been associated with higher rates of postoperative infections and complications. Such studies have not yet been performed in the field of joint replacement surgery. Unlike several other risk factors of infected joint replacements, hyperglycemia is potentially modifiable and therefore its prevalence, predisposing factors and association with postoperative infections are of interest.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hip and knee replacements recipients | Osteoarthritis patients undergoing elective primary hip and knee replacement and being followed-up in this study. |
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| Measure | Description | Time Frame |
|---|---|---|
| Occurrence (and severity) of hyperglycemia following primary hip or knee replacement | Follow-up covers postoperative hospital stay at the operating hospital, that lasts typically 2-5 days. | 3 days (average) |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of surgical-site infections | 1 year | |
| Prevalence of glucose metabolism disorders and metabolic syndrome | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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tertiary care clinic
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| Name | Affiliation | Role |
|---|---|---|
| Teemu Moilanen, MD, PhD | Coxa, Hospital for Joint Replacement | Study Director |
| Esa Jämsen, MD, PhD | Coxa, Hospital for Joint Replacement | Principal Investigator |
| Pasi Nevalainen, MD, PhD | Tampere University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Coxa, Hospital for Joint Replacement | Tampere | 33580 | Finland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25409255 | Result | Jamsen E, Nevalainen PI, Eskelinen A, Kalliovalkama J, Moilanen T. Risk factors for perioperative hyperglycemia in primary hip and knee replacements. Acta Orthop. 2015 Apr;86(2):175-82. doi: 10.3109/17453674.2014.987064. Epub 2014 Nov 18. |
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| ID | Term |
|---|---|
| D006943 | Hyperglycemia |
| D003920 | Diabetes Mellitus |
| D010003 | Osteoarthritis |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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plasma sample (one per patient, collected before surgery)
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |