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| Name | Class |
|---|---|
| Else Kröner Fresenius Foundation | OTHER |
| Stroke Imaging Repositoy (STIR) | UNKNOWN |
| MR Stroke Group | UNKNOWN |
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The aim of the study is to evaluate the use of combined fluid attenuated inversion recovery (FLAIR) imaging and diffusion weighted imaging (DWI) as surrogate marker of lesion age within the first 6 hours of ischemic stroke in order to identify patients ≤ 3 or ≤ 4.5 hours of symptom onset in a large multicenter study hours of ischemic stroke. The investigators hypothesize that the pattern of a visible lesion on DWI together with a negative FLAIR ("DWI-FLAIR mismatch") will identify patients ≤ 3 hours of symptom onset with >80% specificity and positive predictive value.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acute ischemic stroke | Patients with acute ischemic stroke confirmed by acute or follow-up MRI with defined andwell-known symptom onset. |
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| Measure | Description | Time Frame |
|---|---|---|
| Specificity (and 95% CI) of "DWI-FLAIR-mismatch" for the identification of patients ≤3 and ≤4.5 hours | on admission |
| Measure | Description | Time Frame |
|---|---|---|
| Predictors of a "negative FLAIR" in acute ischemic stroke | on admission |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with acute ischemic stroke confirmed by acute or follow-up MRI with defined and well known symptom onset
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| Name | Affiliation | Role |
|---|---|---|
| Götz Thomalla, MD | Uinversity Medical Center Hamburg-Eppendorf | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charite Clinical Center | Berlin | 10117 | Germany | |||
| University Medical Center Hamburg-Eppendorf |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21978972 | Result | Thomalla G, Cheng B, Ebinger M, Hao Q, Tourdias T, Wu O, Kim JS, Breuer L, Singer OC, Warach S, Christensen S, Treszl A, Forkert ND, Galinovic I, Rosenkranz M, Engelhorn T, Kohrmann M, Endres M, Kang DW, Dousset V, Sorensen AG, Liebeskind DS, Fiebach JB, Fiehler J, Gerloff C; STIR and VISTA Imaging Investigators. DWI-FLAIR mismatch for the identification of patients with acute ischaemic stroke within 4.5 h of symptom onset (PRE-FLAIR): a multicentre observational study. Lancet Neurol. 2011 Nov;10(11):978-86. doi: 10.1016/S1474-4422(11)70192-2. Epub 2011 Oct 4. |
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| Hamburg |
| 22524 |
| Germany |
| ID | Term |
|---|---|
| D000083242 | Ischemic Stroke |
| ID | Term |
|---|---|
| D020521 | Stroke |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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