| Primary | Performance Domain Score From the Patient Satisfaction and Preference Questionnaire (PASAPQ) at Week 48 | Patient acceptability was assessed with the Performance Domain score from the PASAPQ. The score is a mean of 7 items on a scale from 0 (very dissatisfied) to 100 (very satisfied). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | unit on a scale | | 48 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| | | Title | Denominators | Categories |
|---|
| | | Title | Measurements |
|---|
| - OG00087.9± 1.27
- OG00178.3± 1.31
- OG00281.7± 1.37
|
|
| | Group IDs | Group Description | Statistical Method | Statistical Comment | P-Value | P-Value Comment | Parameter Type | Parameter Value | Dispersion Type | Dispersion Value | Confidence Interval Sides | Confidence Interval % | CI Lower Limit | CI Upper Limit | CI Lower Limit Comment | CI Upper Limit Comment | Estimate Comment | Tested Non-Inferiority | Non-Inferiority Type | Non-Inferiority Comment | Other Analysis Description |
|---|
| Comparison of Combivent Respimat versus Combivent Inhalation Aerosol | Mixed Models Analysis | Adjusted for baseline and baseline-by-test-day interaction | < 0.0001 | | Mean Difference (Final Values) | 9.6 | | | | 95 | 6.02 | 13.19 | | | | No | Superiority or Other | | | | |
|
| Secondary | Performance Domain Score From the Patient Satisfaction and Preference Questionnaire (PASAPQ) at Week 3 | Patient acceptability was assessed with the Performance Domain score from the PASAPQ. The score is a mean of 7 items on a scale from 0 (very dissatisfied) to 100 (very satisfied). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | unit on a scale | | 3 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Performance Domain Score From the Patient Satisfaction and Preference Questionnaire (PASAPQ) at Week 12 | Patient acceptability was assessed with the Performance Domain score from the PASAPQ. The score is a mean of 7 items on a scale from 0 (very dissatisfied) to 100 (very satisfied). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | unit on a scale | | 12 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Performance Domain Score From the Patient Satisfaction and Preference Questionnaire (PASAPQ) at Week 24 | Patient acceptability was assessed with the Performance Domain score from the PASAPQ. The score is a mean of 7 items on a scale from 0 (very dissatisfied) to 100 (very satisfied). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | unit on a scale | | 24 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Performance Domain Score From the Patient Satisfaction and Preference Questionnaire (PASAPQ) at Week 36 | Patient acceptability was assessed with the Performance Domain score from the PASAPQ. The score is a mean of 7 items on a scale from 0 (very dissatisfied) to 100 (very satisfied). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | unit on a scale | | 36 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Overall Satisfaction Score From the Patient Satisfaction and Preference Questionnaire (PASAPQ) at Week 0 | Patient satisfaction was assessed by asking: "Overall, how satisfied are you with your inhaler?". Responses were made on a scale from 1 (very dissatisfied) to 7 (very satisfied). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Mean | Standard Deviation | units on a scale | | 0 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Overall Satisfaction Score From the Patient Satisfaction and Preference Questionnaire (PASAPQ) at Week 3 | Patient satisfaction was assessed by asking: "Overall, how satisfied are you with your inhaler?". Responses were made on a scale from 1 (very dissatisfied) to 7 (very satisfied). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | unit on a scale | | 3 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Overall Satisfaction Score From the Patient Satisfaction and Preference Questionnaire (PASAPQ) at Week 12 | Patient satisfaction was assessed by asking: "Overall, how satisfied are you with your inhaler?". Responses were made on a scale from 1 (very dissatisfied) to 7 (very satisfied). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | unit on a scale | | 12 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Overall Satisfaction Score From the Patient Satisfaction and Preference Questionnaire (PASAPQ) at Week 24 | Patient satisfaction was assessed by asking: "Overall, how satisfied are you with your inhaler?". Responses were made on a scale from 1 (very dissatisfied) to 7 (very satisfied). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | unit on a scale | | 24 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Overall Satisfaction Score From the Patient Satisfaction and Preference Questionnaire (PASAPQ) at Week 36 | Patient satisfaction was assessed by asking: "Overall, how satisfied are you with your inhaler?". Responses were made on a scale from 1 (very dissatisfied) to 7 (very satisfied). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | unit on a scale | | 36 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Overall Satisfaction Score From the Patient Satisfaction and Preference Questionnaire (PASAPQ) at Week 48 | Patient satisfaction was assessed by asking: "Overall, how satisfied are you with your inhaler?". Responses were made on a scale from 1 (very dissatisfied) to 7 (very satisfied). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | unit on a scale | | 48 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Clinical COPD Questionnaire (CCQ) Symptom Domain Score at Week 0 | CCQ symptom domain score assessed patient feelings or limitations due to their COPD on a scale from 0 (not limited) to 6 (totally limited). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Mean | Standard Deviation | units on a scale | | 0 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Clinical COPD Questionnaire (CCQ) Symptom Domain Score at Week 3 | CCQ symptom domain score assessed patient feelings or limitations due to their COPD on a scale from 0 (not limited) to 6 (totally limited). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | unit on a scale | | 3 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Clinical COPD Questionnaire (CCQ) Symptom Domain Score at Week 12 | CCQ symptom domain score assessed patient feelings or limitations due to their COPD on a scale from 0 (not limited) to 6 (totally limited). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | unit on a scale | | 12 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Clinical COPD Questionnaire (CCQ) Symptom Domain Score at Week 24 | CCQ symptom domain score assessed patient feelings or limitations due to their COPD on a scale from 0 (not limited) to 6 (totally limited). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | unit on a scale | | 24 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Clinical COPD Questionnaire (CCQ) Symptom Domain Score at Week 36 | CCQ symptom domain score assessed patient feelings or limitations due to their COPD on a scale from 0 (not limited) to 6 (totally limited). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | unit on a scale | | 36 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Clinical COPD Questionnaire (CCQ) Symptom Domain Score at Week 48 | CCQ symptom domain score assessed patient feelings or limitations due to their COPD on a scale from 0 (not limited) to 6 (totally limited). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | unit on a scale | | 48 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Physician's Global Evaluation at Week 0 | Physicians evaluated the patient's overall clinical condition on a scale ranging from "poor" (score 1 or 2) to "excellent" (score 7 or 8). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Mean | Standard Deviation | units on a scale | | 0 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Physician's Global Evaluation at Week 3 | Physicians evaluated the patient's overall clinical condition on a scale ranging from "poor" (score 1 or 2) to "excellent" (score 7 or 8). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | unit on a scale | | 3 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Physician's Global Evaluation at Week 12 | Physicians evaluated the patient's overall clinical condition on a scale ranging from "poor" (score 1 or 2) to "excellent" (score 7 or 8). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | unit on a scale | | 12 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Physician's Global Evaluation at Week 24 | Physicians evaluated the patient's overall clinical condition on a scale ranging from "poor" (score 1 or 2) to "excellent" (score 7 or 8). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | unit on a scale | | 24 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Physician's Global Evaluation at Week 36 | Physicians evaluated the patient's overall clinical condition on a scale ranging from "poor" (score 1 or 2) to "excellent" (score 7 or 8). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | unit on a scale | | 36 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Physician's Global Evaluation at Week 48 | Physicians evaluated the patient's overall clinical condition on a scale ranging from "poor" (score 1 or 2) to "excellent" (score 7 or 8). | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | unit on a scale | | 48 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Change From Baseline in FEV1 at Day 1 | Change from test-day baseline in Forced Expiratory Volume in 1 second (FEV1) at 1 hour post dose on test day 1. | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | liters | | baseline, day 1 | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Change From Baseline in FEV1 at Week 12 | Change from test-day baseline in Forced Expiratory Volume in 1 second (FEV1) at 1 hour post dose at Week 12 | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | liters | | baseline, 12 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Change From Baseline in FEV1 at Week 24 | Change from test-day baseline in Forced Expiratory Volume in 1 second (FEV1) at 1 hour post dose at Week 24 | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | liters | | baseline, 24 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Change From Baseline in FEV1 at Week 48 | Change from test-day baseline in Forced Expiratory Volume in 1 second (FEV1) at 1 hour post dose at Week 48 | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | liters | | baseline, 48 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Change From Baseline in FVC at Day 1 | Change from test-day baseline in Forced Vital Capacity (FVC) at 1 hour post dose on test day 1. | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | liters | | baseline, day 1 | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Change From Baseline in FVC at Week 12 | Change from test-day baseline in Forced Vital Capacity (FVC) at 1 hour post dose at Week 12 | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | liters | | baseline, 12 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Change From Baseline in FVC at Week 24 | Change from test-day baseline in Forced Vital Capacity (FVC) at 1 hour post dose at Week 24 | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | liters | | baseline, 24 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Change From Baseline in FVC at Week 48 | Change from test-day baseline in Forced Vital Capacity (FVC) at 1 hour post dose at Week 48 | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | liters | | baseline, 48 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Mean Number of Puffs of Daily Rescue Medication Use in Two Weeks Prior to Week 0 | Mean number of puffs of daily rescue medication use (albuterol use per 24 hour period) in two weeks prior to week 0 | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Mean | Standard Deviation | number of puffs | | 0 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Mean Number of Puffs of Daily Rescue Medication Use in Two Weeks Prior to Week 3 | Mean number of puffs of daily rescue medication use (albuterol use per 24 hour period) in two weeks prior to week 3 | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | number of puffs | | 3 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Mean Number of Puffs of Daily Rescue Medication Use in Two Weeks Prior to Week 12 | Mean number of puffs of daily rescue medication use (albuterol use per 24 hour period) in two weeks prior to week 12 | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | number of puffs | | 12 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Mean Number of Puffs of Daily Rescue Medication Use in Two Weeks Prior to Week 24 | Mean number of puffs of daily rescue medication use (albuterol use per 24 hour period) in two weeks prior to week 24 | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | number of puffs | | 24 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Mean Number of Puffs of Daily Rescue Medication Use in Two Weeks Prior to Week 36 | Mean number of puffs of daily rescue medication use (albuterol use per 24 hour period) in two weeks prior to week 36 | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | number of puffs | | 36 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
| |
| Secondary | Mean Number of Puffs of Daily Rescue Medication Use in Two Weeks Prior to Week 48 | Mean number of puffs of daily rescue medication use (albuterol use per 24 hour period) in two weeks prior to week 48 | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Least Squares Mean | Standard Error | number of puffs | | 48 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
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| Secondary | Number of Patients Having Chronic Obstructive Pulmonary Disease (COPD) Exacerbations | | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Number | | participants | | 48 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
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| Secondary | Number of Patients Having Chronic Obstructive Pulmonary Disease (COPD) Exacerbations Leading to Hospitalization | | Treated Set is defined as all patients who were randomized and received study drug | Posted | | Number | | participants | | 48 weeks | | | | ID | Title | Description |
|---|
| OG000 | Combivent Respimat | ipratropium/albuterol 20/100 micrograms (mcg) 4 per day (qid) | | OG001 | Combivent Inhalation Aerosol | ipratropium bromide and albuterol sulfate 36/206 mcg qid | | OG002 | Atrovent + Albuterol Aerosols | ipratropium bromide 34 mcg, albuterol sulfate 180 mcg qid |
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