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It seems that the aldehydes and NO2, at the levels found indoor, could be the aggravating factors for an allergic response. However this effect has not been demonstrated. The investigators plan to study the effect of exposure to standard doses of these pollutants on the bronchial reactivity as measured by bronchial challenge tests with dust mite extract in volunteers asthmatic, allergic to house dust mite.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| NO2 | Experimental | NO2 400 µg/m3 |
|
| Formaldehyde | Experimental | Formaldehyde 100 µg/m3 |
|
| NO2 + Formaldehyde | Experimental | mixture of Formaldehyde and NO2 |
|
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Formaldehyde and NO2 (Exposure to indoor pollutants) | Other | Exposure to indoor pollutants (Formaldehyde and NO2) in a randomized way, followed by bronchial challenge test with house dust mite extract. |
Inclusion criteria:
Exclusion criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Frederic DE BLAY, MD | Service de Pneumologie, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Unité de Pneumologie, d'Allergologie et de Pathologie Respiratoire de l'Environnement, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg | Strasbourg | 67091 | France |
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| ID | Term |
|---|---|
| D000092542 | Dust Mite Allergy |
| ID | Term |
|---|---|
| D012221 | Rhinitis, Allergic, Perennial |
| D065631 | Rhinitis, Allergic |
| D012220 | Rhinitis |
| D009668 | Nose Diseases |
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| ID | Term |
|---|---|
| D005557 | Formaldehyde |
| ID | Term |
|---|---|
| D000447 | Aldehydes |
| D009930 | Organic Chemicals |
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| Placebo (Exposure to indoor pollutants) | Other | Exposure to indoor pollutants (placebo) in a randomized way, followed by bronchial challenge test with house dust mite extract. |
|
| D012140 |
| Respiratory Tract Diseases |
| D012130 | Respiratory Hypersensitivity |
| D010038 | Otorhinolaryngologic Diseases |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |