Identifying Predictors of Response to Antipsychotics Using a Treatment Algorithm

Identifying Predictors of Response in 12 Weeks of Treatment With Antipsychotics Using a Treatment Algorithm for Schizophrenia

The objective of this study is to evaluate predictors of response to antipsychotic medication in subjects with schizophrenia. The investigators will evaluate psychopathology,brain MRI, genetics and neuropsychological profile. Two groups of treatment will be compared: first generation antipsychotics vs. second generation antipsychotics. Participants will be randomized to one of the groups. Trial duration: 12 weeks.

Inclusion Criteria:

• Schizophrenia or schizoaffective disorder
• Age: 18-45 years olde
• Less than 10 years of diagnosis
• Acute exacerbation of psychotic symptoms

Exclusion Criteria:

• Use of clozapine
• Clinical unstable disease
• Delirium and cognitive disorders