Not enough patients within the time frame to allow for a meaningful study.

The purpose of this study is to determine whether injections of ranibizumab into the eye are safe and well tolerated when given to subjects in multiple doses.

Choroidal neovascularization is a hallmark of angioid streaks, and presumably VEGF-driven. Ranibizumab has been shown to be effective in CNV secondary to age-related macular degeneration. Therefore, we hypothesize that ranibizumab may be efficacious in the treatment of CNV secondary to angioid streaks

Inclusion Criteria:

• Ability to provide written informed consent and comply with study assessments for the full duration of the study
• Age > 18 years
• Angioid streaks
• Subfoveal CNV of recent onset with the following characteristics
• Absence of subfoveal fibrosis
• Fibrosis less than 25% of the lesion
• Presence of blood, subretinal fluid, and/or lipid
• New onset symptoms within 12 weeks
• Visual acuity 20/40 to 20/800 on an ETDRS chart

Exclusion Criteria:

• Prior treatment of subfoveal CNV in the study eye
• Age-related macular degeneration
• Uncontrolled glaucoma
• High myopia (> -10.00 D spherical equivalent)
• Prior retinal detachment
• Media opacity preventing adequate view of the retina
• Planned cataract surgery in the next 3 months
• Current chemotherapy for cancer
• Immunocompromised state
• Pregnancy (positive pregnancy test) or lactation
• Premenopausal women not using adequate contraception.
• Any other condition that the investigator believes would pose a significant hazard to the subject if the investigational therapy were initiated
• Participation in another simultaneous medical investigation or trial
• History of any previous treatment for angioid streaks