A Comparison of Prasugrel at the Time of Percutaneous Coronary Intervention (PCI) Or as Pretreatment At the Time of Diagnosis in Patients With Non-ST-Elevation Myocardial Infarction (NSTEMI): The ACCOAST Study
A Comparison of Prasugrel at the Time of Percutaneous Coronary Intervention (PCI) Or as Pretreatment At the Time of Diagnosis in Patients With Non-ST-Elevation Myocardial Infarction (NSTEMI): The ACCOAST Study
The purpose of this trial is to investigate the potential benefits/risks regarding pretreatment with prasugrel in non-ST-elevation myocardial infarction (NSTEMI) participants with elevated troponin scheduled for coronary angiography/percutaneous coronary intervention (PCI).
This trial consists of two arms. One arm is a non pre-treatment arm. Participants in this arm will receive placebo immediately after NSTEMI diagnosis and prior to the diagnostic coronary angiography. A 60 mg prasugrel loading dose will be given immediately after coronary angiography when proceeding to PCI. Subsequently, participants will receive daily maintenance doses of prasugrel until day 30. Participants who are greater than or equal to 75 years of age or who have a body weight less than 60 kilograms (kg) will receive 5 mg oral dose daily. All others will receive a 10 mg oral daily maintenance dose for 30 days.
The other arm is a pre-treatment arm where participants will receive a split loading dose regimen with 30 mg of prasugrel administered immediately after NSTEMI diagnosis and prior to diagnostic coronary angiography. The remainder of the loading dose (30 mg) will be administered when the participants are proceeding to PCI. Subsequently, participants will receive daily maintenance doses of prasugrel until day 30. Participants who are greater than or equal to 75 years of age or who have a body weight less than 60 kg will receive 5 mg oral dose daily. All others will receive a 10 mg oral daily maintenance dose for 30 days.
Inclusion Criteria:
Exclusion Criteria:
Braunau am Inn, 5280, Austria
Graz, 8020, Austria
Linz, 4020, Austria
Vienna, A1090, Austria
Bonheiden, 2820, Belgium
Bruges, 8000, Belgium
Charleroi, 6000, Belgium
Genk, 3600, Belgium
Leuven, 3000, Belgium
Yvoir, 5530, Belgium
Calgary, Alberta T2N 2T9, Canada
Vancouver, British Columbia Vancouver, Canada
Toronto, Ontario M5B 1W8, Canada
Montreal, Quebec H4J 1C5, Canada
Sainte-Foy, Quebec G1V 4G5, Canada
Saskatoon, Saskatchewan S7N 0W8, Canada
Brno, 625 00, Czechia
Hradec Králové, 500 05, Czechia
Olomouc, 775 20, Czechia
Pilsen, 30460, Czechia
Prague, 169 02, Czechia
Ústí nad Labem, 40113, Czechia
Turku, 20521, Finland
Bastia, 20600, France
Bron, 69500, France
Caluire-et-Cuire, 69300, France
Cannes, 06401, France
Châteauroux, 36019, France
Corbeil-Essonnes, 91106, France
Lagny-sur-Marne, 77405, France
Le Coudray, 28630, France
Lille, 59037, France
Lyon, 69317, France
Marseille, 13015, France
Metz, 57085, France
Metz-Tessy, 74370, France
Montauban, 82017, France
Montreuil, 93105, France
Nîmes, 30029, France
Paris, 75743, France
Pau, 64046, France
Pierre-Bénite, 69495, France
Rennes, 35033, France
Toulouse, 31076, France
Valence, 26953, France
Vannes, 56017, France
Vienne, 38209, France
Villeurbanne, 69100, France
Bad Nauheim, 61231, Germany
Bad Segeberg, 23795, Germany
Bochum, 44791, Germany
Bonn, 53105, Germany
Coburg, 96450, Germany
Dachau, 85221, Germany
Eutin, 23701, Germany
Frankfurt, 60596, Germany
Halle, 06120, Germany
Hamburg, 20099, Germany
Hanover, 30625, Germany
Heidelberg, D-69120, Germany
Jena, 07740, Germany
Kassel, 34125, Germany
Leipzig, 04289, Germany
Ludwigshafen, 67063, Germany
Mainz, 55101, Germany
Munich, 80336, Germany
Rastatt, 76437, Germany
Rostock, 18057, Germany
Villingen-Schwenningen, 78050, Germany
Balatonfüred, 8230, Hungary
Budapest, 1096, Hungary
Pécs, 7624, Hungary
Zalaegerszeg, 8900, Hungary
Beer Yaakov, 70300, Israel
Haifa, 34362, Israel
Jerusalem, 91120, Israel
Kfar Saba, 44281, Israel
Nahariya, 22100, Israel
Tel Aviv, 64239, Israel
Tiberias, 15208, Israel
Arezzo, 52100, Italy
Chieti, 66013, Italy
Grosseto, 58100, Italy
Legnano, 20025, Italy
Lucca, Italy
Massa, 54100, Italy
Monza, 20900, Italy
Naples, 80100, Italy
Pavia, 27100, Italy
Perugia, 06156, Italy
Pisa, 56100, Italy
Prato, 50047, Italy
Reggio Emilia, 42100, Italy
Rome, 00100, Italy
Torino, 10100, Italy
Udine, 33100, Italy
Venezia, 30035, Italy
Liepāja, 3414, Latvia
Riga, 1038, Latvia
Kaunas, LT-50009, Lithuania
Klaipedos, 92288, Lithuania
Vilnius, LT-08661, Lithuania
Amsterdam, 1081 HV, Netherlands
Eindhoven, 5623 EJ, Netherlands
Leeuwarden, 8934 AD, Netherlands
Nieuwegein, 3435 CM, Netherlands
Nijmegen, 6500 HB, Netherlands
Tiel, 4002 WP, Netherlands
Zwolle, 8025 AB, Netherlands
Bełchatów, 97-400, Poland
Chrzanów, 32-500, Poland
Grodzisk Mazowiecki, 05-825, Poland
Katowice, 40-635, Poland
Krakow, 31-501, Poland
Kłodzko, 57-300, Poland
Lodz, 91-347, Poland
Lublin, 20-954, Poland
Mielec, 39-300, Poland
Nałęczów, 24-140, Poland
Nowy Sącz, 33-300, Poland
Nowy Targ, 34-400, Poland
Nysa, 48-300, Poland
Ostrowiec Świętokrzyski, 27-400, Poland
Oświęcim, 32-600, Poland
Polanica-Zdrój, 57-320, Poland
Puławy, 24-100, Poland
Radom, 26-617, Poland
Sanok, 38-500, Poland
Stalowa Wola, 37-450, Poland
Starogard Gdański, 82-200, Poland
Tarnów, 33-100, Poland
Warsaw, 04-628, Poland
Wejherowo, 84-200, Poland
Wroclaw, 53-114, Poland
Braga, 4710-243, Portugal
Carnaxide, 2794-006, Portugal
Faro, 8000-386, Portugal
Leiria, 2410-197, Portugal
Bucharest, 050098, Romania
Târgu Mureş, 540136, Romania
Banská Bystrica, 97401, Slovakia
Košice, 04011, Slovakia
Nitra, 94901, Slovakia
Gothenburg, 413 45, Sweden
Adana, 1330, Turkey (Türkiye)
Ankara, 06520, Turkey (Türkiye)
Antalya, 07070, Turkey (Türkiye)
Fatih, 34300, Turkey (Türkiye)
Isparta, 32100, Turkey (Türkiye)
Istanbul, 34303, Turkey (Türkiye)
Kayseri, 38039, Turkey (Türkiye)
Kocaeli, 41900, Turkey (Türkiye)