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The aim of the study was to assess of the influence of atorvastatin on selected indicators of an inflammatory condition, function of the left ventricle and factors affecting the occurrence of undesired events like rehospitalizations and mortality in patients with dilated cardiomyopathy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Atorvastatin |
| ||
| No statin |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tulip | Drug | Patients were divided into two groups: A, who were administered atorvastatin 40 mg daily for two months and 10 mg for next 4 months; and group B, 4 who were treated according to current guidelines without statin therapy. |
| Measure | Description | Time Frame |
|---|---|---|
| left ventricular function | 2 months |
| Measure | Description | Time Frame |
|---|---|---|
| mortality | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with dilated cardiomyopathy (according ESC 2007) with EF≤40% as documented by echocardiography were included.
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| Name | Affiliation | Role |
|---|---|---|
| Agata Bielecka-Dabrowa, PhD | Department of Hypertension UM Lodz | Principal Investigator |
| Maciej Banach, Assoc. Prof. | Department of Hypertension UM Lodz | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18698552 | Background | Bielecka-Dabrowa A, Wierzbicka M, Dabrowa M, Goch A. New methods in laboratory diagnostics of dilated cardiomyopathy. Cardiol J. 2008;15(4):388-95. | |
| 18350717 | Background | Bielecka-Dabrowa A, Wierzbicka M, Goch JH. [Proinflammatory cytokines in cardiovascular diseases as potential therapeutic target]. Wiad Lek. 2007;60(9-10):433-8. Polish. |
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| ID | Term |
|---|---|
| D002311 | Cardiomyopathy, Dilated |
| D006333 | Heart Failure |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D006332 | Cardiomegaly |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D009202 | Cardiomyopathies |
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| ID | Term |
|---|---|
| D020728 | Transurethral Resection of Prostate |
| ID | Term |
|---|---|
| D011468 | Prostatectomy |
| D013521 | Urologic Surgical Procedures, Male |
| D013520 | Urologic Surgical Procedures |
| D013519 | Urogenital Surgical Procedures |
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blood68
| 20178563 | Derived | Bielecka-Dabrowa A, Goch JH, Rysz J, Maciejewski M, Desai R, Aronow WS, Banach M. Influence of co-existing atrial fibrillation on the efficacy of atorvastatin treatment in patients with dilated cardiomyopathy: a pilot study. Lipids Health Dis. 2010 Feb 23;9:21. doi: 10.1186/1476-511X-9-21. |
| 19946241 | Derived | Bielecka-Dabrowa A, Goch JH, Mikhailidis DP, Rysz J, Maciejewski M, Banach M. The influence of atorvastatin on parameters of inflammation and function of the left ventricle in patients with dilated cardiomyopathy. Med Sci Monit. 2009 Dec;15(12):MS12-23. |
| D000083083 |
| Laminopathies |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D013514 | Surgical Procedures, Operative |