Genetic Susceptibility, Environment & Prostate Cancer Risk
Genetic Susceptibility, Environment & Prostate Cancer Risk
RATIONALE: Gathering information about genetic and environmental factors may help doctors learn more about a person's risk for developing prostate cancer.
PURPOSE: This research project is studying genes, environment, and prostate cancer risk in patients with or without prostate cancer.
OBJECTIVES:
OUTLINE: Probands undergo blood and saliva sample collection for fatty acid, DNA, and polymorphism analyses. Archived blood and tissue samples from probands who previously participated in Dr. Shannon's Diet and Prostate Cancer Risk study are also analyzed. Medical records of probands are reviewed for demographics, history and course of disease, and clinical laboratory test results.
All probands completed the "Genetic Risk Easy Assessment Tool Family History of Cancer" and "Diet History and Environmental Risk Factor" questionnaires at baseline. If a proband previously participated on our Diet and Prostate Cancer Risk study, he was asked to complete the "Changes in Diet, Prescriptions, Supplementals and Herbal Remedies" questionnaire in addition to the "Genetic Risk Easy Assessment Tool Family History of Cancer" questionnaire at baseline for this study.
PROJECTED ACCRUAL: A total of 750 participants will be accrued for this study.
DISEASE CHARACTERISTICS:
Meets 1 of the following criteria:
Prior diagnosis of prostate cancer or negative prostate biopsy AND previously participated in Dr. Shannon's Diet and Prostate Cancer Risk study and consented to future studies (proband)
Referred to the Portland VA Medical Center urology clinic for a prostate biopsy (proband)
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY: