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| ID | Type | Description | Link |
|---|---|---|---|
| VAMC-OR-M1736 | |||
| CPC-07129-L |
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RATIONALE: Gathering information about genetic and environmental factors may help doctors learn more about a person's risk for developing prostate cancer.
PURPOSE: This research project is studying genes, environment, and prostate cancer risk in patients with or without prostate cancer.
OBJECTIVES:
OUTLINE: Probands undergo blood and saliva sample collection for fatty acid, DNA, and polymorphism analyses. Archived blood and tissue samples from probands who previously participated in Dr. Shannon's Diet and Prostate Cancer Risk study are also analyzed. Medical records of probands are reviewed for demographics, history and course of disease, and clinical laboratory test results.
All probands completed the "Genetic Risk Easy Assessment Tool Family History of Cancer" and "Diet History and Environmental Risk Factor" questionnaires at baseline. If a proband previously participated on our Diet and Prostate Cancer Risk study, he was asked to complete the "Changes in Diet, Prescriptions, Supplementals and Herbal Remedies" questionnaire in addition to the "Genetic Risk Easy Assessment Tool Family History of Cancer" questionnaire at baseline for this study.
PROJECTED ACCRUAL: A total of 750 participants will be accrued for this study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Probands |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DNA analysis | Genetic | saliva samples will be collected from men (probands) who join the study. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Association between variation in genes involved in reactive oxygen species detoxification, oxidative stress response, and prostate cancer risk | Using saliva samples, we conducted analysis on probands' oxidative stress pathway genes and whether these were associated with prostate cancer risk. | through study completion; 1 day |
| Association between blood fatty acids and prostate cancer risk | Using blood samples, we conducted analysis on probands' fatty acid level and whether these were associated with prostate cancer risk. | through study completion; 1 day |
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DISEASE CHARACTERISTICS:
Meets 1 of the following criteria:
Prior diagnosis of prostate cancer or negative prostate biopsy AND previously participated in Dr. Shannon's Diet and Prostate Cancer Risk study and consented to future studies (proband)
Referred to the Portland VA Medical Center urology clinic for a prostate biopsy (proband)
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
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| Name | Affiliation | Role |
|---|---|---|
| Jackilen Shannon, PhD | Portland VA Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Veterans Affairs Medical Center - Portland | Portland | Oregon | 97239 | United States |
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10ml blood specimen drawn from probands consented in person at the Portland VA; saliva samples from all consented probands (N = 748).
| polymorphism analysis | Genetic | we will genotype DNA samples (buccal) from all probands and conduct a traditional case-control analysis |
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| laboratory biomarker analysis | Other | 10ml blood specimen will be obtained and processed (on probands locally-consented and/or those who have an appointment at the VA in Portland, Oregon) to allow for analyses of erythrocyte fatty acids and future nutrient and DNA analyses |
|
| medical chart review | Other | PSA results, prostate biopsy pathology reports and clinician notes related to the biopsy are reviewed for final data analysis |
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| questionnaire administration | Other | probands are asked to complete questionnaires on 1) family history of cancer, 2) diet history over the past year, 3) employment environment and risk factors and/or 4) changes to diet, medications since enrollment in originating case control study |
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| evaluation of cancer risk factors | Procedure | pathology reports will be reviewed for probands whose prostate biopsies reveal cancer; these factors will be evaluated for cancer risk factors |
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| study of high risk factors | Procedure | prostate biopsy pathology reports will be reviewed for high risk factors |
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| ID | Term |
|---|---|
| C537243 | Prostate cancer, familial |
| D011471 | Prostatic Neoplasms |
| ID | Term |
|---|---|
| D005834 | Genital Neoplasms, Male |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D011469 | Prostatic Diseases |
| D052801 | Male Urogenital Diseases |
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| ID | Term |
|---|---|
| D054458 | Amplified Fragment Length Polymorphism Analysis |
| ID | Term |
|---|---|
| D016172 | DNA Fingerprinting |
| D005821 | Genetic Techniques |
| D008919 | Investigative Techniques |
| D016133 | Polymerase Chain Reaction |
| D021141 | Nucleic Acid Amplification Techniques |
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