The purpose of this study is to determine the safety and toleration of single and multiple doses of PF-04531083. (To investigate the plasma and urinary pharmacokinetics of PF-04531083 and its metabolites, following single and multiple dose administration in healthy male and/or female subjects; and to determine whether PF-04531083 raises levels of enzymes involved in metabolism of other drugs following multiple dosing).

Inclusion Criteria:

• Healthy male and/or female subjects btween the ages of 18-55 years
• Body Mass Index (BMI) of 15.5 to 30.5 and a total body weight greater than 50kg (110 lbs).

Exclusion Criteria:

• Evidence or history of clinically signifcant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease.
• A positive urine drug screen.
• History of regular alcohol consumption exceeding 21 drinks/week within 6 months of screening
• Use of tobacco or nicotine containing products in excess of the equivalent of 5 cigarettes per day.
• Pregnant or nursing females; females of childbearing potentioal who are unwilling or unable to use an acceptable method on contraception.