A 1-year multicenter, randomized, single-blinded, phase II trial, stratified on HAART. The purpose of this trial is to evaluate the immunogenicity and safety of a A(H1N1)French National Agency for Research on AIDS and Viral Hepatitis influenza vaccine, administered with or without adjuvant, in HIV-infected patients after one or two injections.

Inclusion Criteria:

• Age ≥ 18 years
• Able to give written consent
• Covered by French Social Security
• HIV-infected (infection attested by the patient's chart)
• Patients treated by HAART for at least 6 months, with a viral load inferior to 50 copies/mL on at least 2 last visits
• Patients without any treatment for HIV for at least 6 months and without any indication to start a treatment in the following 3 months
• Patients followed for their HIV-infection in an ANRS center and whose home is close to the center in case of influenza-like illness, consultation and hospitalization in the center where he is followed if necessary
• For women with childbearing potential, using an effective method of contraception, and willing to undergo urine pregnancy tests prior to each vaccination.

Exclusion Criteria:

• Pregnancy
• Receipt of chemotherapy, immunotherapy (IL2, IL7, IV Ig), or corticosteroids within 3 months prior to enrolment
• Thrombopenia inferior to 20 000/mm3
• Febrile episode (at least 38°C rectal or if at least 37,5°C measured orally) within one week prior to vaccination
• Opportunistic infection (treated for less than 1 month)
• Co-infection with HCV and treated with IFNa
• Influenza (clinically or virologically documented) in the last 6 months
• History of documented auto-immune disease (lupus, systemic inflammatory disease, ...)
• Child C cirrhosis
• Solid organ transplant recipient
• Intolerance to 1 component of the vaccine
• Other immunization received within 3 weeks prior to inclusion or planned until after the last vaccine injection.