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The objectives of the current study are
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PTSD group | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| escitalopram (lexapro) | Drug | 0 - 4 week: 10 mg escitalopram a day 5 - 8 week: 20 mg escitalopram a day |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes from baseline in brain structure, function, and biochemical metabolism, analyzed using the computational approach | Baseline, 8th weeks | |
| Change from baseline in Clinician-administered PTSD scale scores at 1st week | Baseline, 1st week | |
| Change from baseline in Clinician-administered PTSD scale scores at 4th weeks | Baseline, 4th weeks | |
| Change from baseline in Clinician-administered PTSD scale scores at 8th weeks | Baseline, 8th weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in Hamilton depression rating scale scores at 1st week | Baseline, 1st week | |
| Change from baseline in Hamilton anxiety rating scale scores at 1st week | Baseline, 1st week | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Junghyun H Lee, MD, MS | Contact | 82-10-3453-1744 | leejunghyun1@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| In Kyoon Lyoo, MD, PhD, MMS | Seoul National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Recruiting | Seoul | South Korea |
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| ID | Term |
|---|---|
| D013313 | Stress Disorders, Post-Traumatic |
| ID | Term |
|---|---|
| D040921 | Stress Disorders, Traumatic |
| D000068099 | Trauma and Stressor Related Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D000089983 | Escitalopram |
| ID | Term |
|---|---|
| D011437 | Propylamines |
| D000588 | Amines |
| D009930 | Organic Chemicals |
| D009570 | Nitriles |
| D001572 |
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| Number of participants with adverse events |
| 1st week |
| Change from baseline in Hamilton depression rating scale scores at 4th weeks | Baseline, 4th weeks |
| Change from baseline in Hamilton depression rating scale scores at 8th weeks | Baseline, 8th weeks |
| Change from baseline in Hamilton anxiety rating scale scores at 4th weeks | Baseline, 4th weeks |
| Change from baseline in Hamilton anxiety rating scale scores at 8th weeks | Baseline, 8th weeks |
| Number of participants with adverse events | 4th weeks |
| Number of participants with adverse events | 8th weeks |
| Benzofurans |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |