TRAUMA HELP: Healing and Analgesia With Propranolol

Phase IIB Study: TRAUMA HELP: Healing and Analgesia With Propranolol

The purpose of this study is to determine whether propranolol can decrease pain symptoms in a common subset of patients admitted to a trauma center after injury.

The main purpose of this pilot study is to investigate Propranolol's utility in the trauma population. Specifically, to see if it reduces pain scores post-injury.

Inclusion Criteria:

• at least one fracture
• ages 18-60 yrs
• pain score >= 4
• speak and read English

Exclusion Criteria:

• gunshot, stab wound, or assault
• paraplegia/quadriplegia
• pregnancy
• psychotic, suicidal, or homicidal
• hepatic, kidney failure
• clinically unstable or intubated at time of recruitment
• hyperthyroidism
• propranolol use within the last 6 months
• significant bradycardia
• cancer (except basal cell)
• peripheral vascular disease
• heart block > 1 degree
• breastfeeding
• congestive heart failure