Unanticipated delays due to sterilization/stabilization testing of GLP-1.

To determine whether treatment with the diabetes medication, Januvia (sitagliptin), with or without another diabetes medicine, Actos (pioglitazone), will improve insulin secretion and insulin response individuals with Impaired Glucose Tolerance (IGT), a form of prediabetes.

Inclusion Criteria:

• Impaired glucose tolerance (IGT) by oral glucose tolerance test

Exclusion Criteria:

• History of diabetes mellitus
• History of congestive heart failure
• History of coronary artery disease or other macrovascular disease (stroke, peripheral vascular disease)
• History of liver disease (ALT or AST >2.5 times the upper limit of normals)
• History of renal disease (serum creatinine >1.5 mg/dl)
• History of severe osteoporosis (frequent fractures, failure on osteoporosis treatment)
• Current treatment with glucocorticoids
• History of immune disorder, including HIV
• Women of child-bearing age who are pregnant, desire to become pregnant, are breastfeeding, or who refuse to take the recommended birth control measures