The study is recruiting 50 patients initiating or switching to Atripla and comparing them to 250 individuals previously followed in a prospective study of HIV+ low income individuals recruited from homeless shelters, single room occupancy hotels and free meal food lines as part of the UCSF Reach Study. Adherence will be measured through monthly unannounced pill counts and electronic medication monitors.

Inclusion Criteria:

• 18+ years old;
• HIV+;
• Initiating Atripla within 6-months of recruitment;
• Lives in the Tenderloin, South of Market, or Mission District San Francisco;
• Capable of providing informed consent; and
• Willing to complete all study procedures.

Exclusion Criteria:

• Intoxication, cognitive dysfunction or psychosis will preclude potential subjects from informed consent.

HIV infected, marginally housed