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| Name | Class |
|---|---|
| Abbott Nutrition | INDUSTRY |
| GTC Nutrition | INDUSTRY |
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Fructooligosaccharides (FOS) are believed to have positive effects on calcium absorption and bone accrual during growth. This study aims to see whether the addition of fiber in the form of FOS to a calcium-containing beverage will increase calcium absorption. During two clinical visits, participants will receive a beverage containing a small amount of calcium, supplemented with either no dietary fiber or a small amount of fiber. Height, weight, bone density and geometry, calcium absorption, and physical fitness will be measured. The effects of this fiber intervention may provide support for improving bone health with minimal fiber supplementation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No Fructooligosaccharide | Placebo Comparator | 0 g fructooligosaccharide added to calcium-containing beverage |
|
| 3 g Fructooligosaccharide | Active Comparator | 3 g fructooligosaccharide added to calcium-containing beverage |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fructooligosaccharide | Dietary Supplement | Zero or 3 g of a fructooligosaccharide will be administered in a beverage containing 300 mg total calcium as well as 15 mg 44Ca (calcium carbonate). Participants will be given one of the above beverages in addition to intravenously receiving 5 mg 43Ca (calcium chloride)in 10 ml saline. |
| Measure | Description | Time Frame |
|---|---|---|
| Fractional Calcium Absorption | 24 h urine and 3 h blood |
| Measure | Description | Time Frame |
|---|---|---|
| Bone density and geometry measured with peripheral quantitative computed tomography (pQCT) | Initial visit |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Connie M Weaver, PhD | Purdue University | Principal Investigator |
| Berdine R Martin, PhD | Purdue University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Purdue University | West Lafayette | Indiana | 47907 | United States |
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| ID | Term |
|---|---|
| D010024 | Osteoporosis |
| ID | Term |
|---|---|
| D001851 | Bone Diseases, Metabolic |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
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| ID | Term |
|---|---|
| C116580 | fructooligosaccharide |
| D004043 | Dietary Fiber |
| D002118 | Calcium |
| ID | Term |
|---|---|
| D004040 | Dietary Carbohydrates |
| D002241 | Carbohydrates |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
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|
|
| D009750 |
| Nutritional and Metabolic Diseases |
| D010829 |
| Physiological Phenomena |
| D019602 | Food and Beverages |
| D008673 | Metals, Alkaline Earth |
| D004602 | Elements |
| D007287 | Inorganic Chemicals |
| D008670 | Metals |
| D001779 | Blood Coagulation Factors |
| D001685 | Biological Factors |