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| ID | Type | Description | Link |
|---|---|---|---|
| NCI-2009-00325 | Registry Identifier | CTRP (Clinical Trial Reporting Program) | |
| CDR0000271322 | |||
| COG-ABTR02B1 | |||
| ABTR02B1 | |||
| ABTR02B1 | Other Identifier | Childrens Oncology Group | |
| ABTR02B1 | Other Identifier | CTEP | |
| U10CA098543 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
This research study is looking at biomarkers in DNA samples from patients with acute lymphoblastic leukemia or acute myeloid leukemia. Studying samples of DNA from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
PRIMARY OBJECTIVES:
I. Collect DNA samples from patients with cytogenetically, well characterized, and uniformly treated acute lymphoblastic leukemia or acute myeloid leukemia for use in analysis of a wide range of host factors influencing etiology and outcome of the disease.
II. Identify host factors that can be determined at onset of treatment to predict outcome of chemotherapy, and thus modify the therapy administered.
OUTLINE:
Previously collected DNA samples are analyzed for polymorphisms at a variety of loci. Gene expression and expression profiles are correlated with genotype and therapy outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ancillary-Correlative (genetic polymorphisms) | Previously collected DNA samples are analyzed for polymorphisms at a variety of loci. Gene expression and expression profiles are correlated with genotype and therapy outcomes. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Laboratory Biomarker Analysis | Other | Correlative studies |
|
| Measure | Description | Time Frame |
|---|---|---|
| Differences in induction outcome, dichotomized into complete remission or no remission | Assessed with Fisher's exact test. | Up to 8 years |
| Differences in induction outcome, dichotomized into complete remission or no remission | Assessed with Pearson's chi square statistic test | Up to 8 years |
| Differences in overall survival | Evaluated using the log rank statistic. | Up to 8 years |
| Disease-free survival (DFS) | Evaluated using the log rank statistic. | Time from the end of induction to relapse or death, assessed up to 8 years |
| Relapse-free survival | Evaluated using the logrank statistic. | Time from the end of induction to marrow relapse or death from progressive disease, censoring on deaths from other causes, assessed up to 8 years |
| Etiology of leukemia: Chi square test | Chi square test will be used to determine the differences in distribution of genotypes between cases and controls. | Up to 8 years |
| Etiology of leukemia: Fisher's exact test | Fisher's exact test will be used to determine the differences in distribution of genotypes between cases and controls. | Up to 8 years |
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Inclusion Criteria:
DNA samples available from patients meeting the following criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stella Davies | Children's Oncology Group | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Childrens Oncology Group | Philadelphia | Pennsylvania | 19104 | United States |
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| ID | Term |
|---|---|
| D015479 | Leukemia, Myelomonocytic, Acute |
| D015473 | Leukemia, Promyelocytic, Acute |
| D054198 | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
| ID | Term |
|---|---|
| D007951 | Leukemia, Myeloid |
| D007938 | Leukemia |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D015470 | Leukemia, Myeloid, Acute |
| D007945 | Leukemia, Lymphoid |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
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