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| Name | Class |
|---|---|
| Ferring Pharmaceuticals | INDUSTRY |
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This study is being done to identify if certain sequences (patterns) of key genes (called polymorphisms) may predict a response to fertility medications. The investigators will also determine if the individual response to fertility medications affects pregnancy rates in in-vitro fertilization.
All IVF patients who meet inclusion criteria and not exclusion criteria will be asked to participate in this study. Upon consent, a blood sample will be obtained in 2 EDTA containing lavender topped tubes before, during or within 3 months after their IVF cycle. Genomic DNA will be extracted and saved for genotyping.
The Investigators will collect data on each individual's age, ethnic background, and estradiol levels on the day of hCG administration, total gonadotropin amount, clinical pregnancy rates, basal FSH levels, and occurrence of OHSS. The Investigators will then analyze all samples from all patients for their FSH receptor genotypes.
Patients will be compensated $75 via a check within 6-8 weeks of their blood drawn.
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| Measure | Description | Time Frame |
|---|---|---|
| The primary outcome measure is to evaluate the frequency of FSH receptor polymorphisms in our population. | The investigators are looking to quantify how often certain FSH receptor Polymorphisms occur in the population and cetain racial groups. We will be looking at patient's race along with the laboratory results. | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| The secondary outcome is to further clarify the variation in response to FSH due to FSH receptor polymorphisms using the protocols largely used in the United States, including our center. | 3 years |
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Inclusion Criteria:
Exclusion Criteria patients who have:
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Patients undergoing in-vitro fertilization will be recruited. Inclusion criteria will limit the patient population to those patients most likely to have normal ovarian function since age or disease related ovarian dysfunction will confound interpretation of our results.
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| Name | Affiliation | Role |
|---|---|---|
| Aimee Seungdamrong, MD | University Reproductive Associates | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Reproductive Associates | Hasbrouck Heights | New Jersey | 07604 | United States | ||
| University Reproductive Associates |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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2 EDTA containing lavender topped tubes will be collected before, during or within 3 months after an IVF cycle. Genomic DNA will be extracted and saved for genotyping.
| Hoboken |
| New Jersey |
| 07030 |
| United States |