A Study of Endostar Combined With Chemotherapy for Treatment of Osteosarcoma

A Randomized, Controlled Multicenter Trial of Endostar Combined With Chemotherapy for Treatment of Osteosarcoma

Purpose: This study will assess the safety and efficacy of Endostar combined with chemotherapy in osteosarcoma patients.

Inclusion Criteria:

• Patients with histologically confirmed osteosarcoma, who have no evidence of metastasis
• At least one measurable lesion
• Life expectancy > 3 months
• ECOG performance status 0-2
• Adequate hematologic, cardiac, renal, and hepatic function
• Patients with prior chemotherapy should have at least 4 weeks clearance period before entering this study

Exclusion Criteria:

• Evidence of metastasis
• Serious infection
• Evidence of bleeding diathesis
• Significant cardiovascular disease
• Pregnant or lactating woman
• Allergic to E.coli preparation