Combination Deplin® and Antidepressant Therapy for a Major Depressive Episode (MDE)- a Retrospective Analysis

Combination Deplin® and Antidepressant Therapy Compared to Antidepressant Therapy Alone for an Episode of Major Depression- a Retrospective Analysis

This is a retrospective chart review study to determine if Deplin® 7.5mg-15mg combined with an antidepressant is better than an antidepressant alone in adults with major depression.

Inclusion Criteria:

• Males or females age 18-70
• The active arm (Arm #1) includes randomly selected 100-125 charts of patients with a primary diagnosis of major depression and a CGI-S of ≥4 who began Deplin and SSRI or SNRI therapy at the same time beginning in January 2007 to the present; and, Control group (Arm #2) includes randomly selected 125-150 charts of patients with a primary diagnosis of major depression who began SSRI or SNRI therapy matched in severity (CGI-S of ≥4)

Exclusion Criteria:

• Folic acid >400 mcg taken at any time during the study
• Psychotic features in the current episode or a history of psychotic features
• Any bipolar disorder (current or past) or any psychotic disorder (current or past)
• Current or past treatment with vagus nerve stimulation, ECT, or transcranial magnetic stimulation
• Antipsychotic therapy in conjunction with their antidepressant currently or in past 4 weeks