A 4 week intake of drug to find a natural substance that may modify energy balance and may enhance health in combination with lifestyle changes with possible decrease in body weight.

This study is a double-blind, placebo-controlled, single center, randomized, parallel arm clinical trial to test the impact of Dihydrocapsiate (placebo, 3 and 9 mg/d) ingested for 4 weeks on resting metabolic rate and fat oxidation measured by indirect calorimetry.

Inclusion Criteria:

• Men between 20-60 years old
• Healthy as assessed by medical history and standard medical exam
• Weight-stable
• Body mass index of 25 to 34.9 kg/m2
• Non-smoker
• Sedentary lifestyle: not being physically active grater than 3 days/week for 20 min each time for the previous 6 months, and not participating in regular resistance exercise.

Exclusion Criteria:

• Subjects enrolled in a diet to increase or decrease body weight
• Special diet or food aversiions to common foods
• Has allergy to chilli pepper
• Eating chilli peppers on a daily basis
• Usually consuming more than 2 cups of tea or coffee/day
• Usually consuming more than 4 cans of caffeinated soft drinks a day
• Usually consuming more than 3 standard alcohol drinks/day
• Regular use of medications (weight loss drugs, drugs affecting energy metabolism, drugs for depression)
• Usual intake of illicit substances
• Claustrophobia
• Participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study