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| ID | Type | Description | Link |
|---|---|---|---|
| NAF 3.4.09.002 | Other Grant/Funding Number | Dutch Asthma Foundation |
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| Name | Class |
|---|---|
| The Netherlands Asthma Foundation | OTHER |
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The purpose of this study is to determine the efficacy of a multifactorial intervention with weight reduction, behavioural therapy, and physical exercise on the severity and control of asthma in obese children.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Multifaceted intervention | Experimental | Multifaceted intervention:physical exercise, nutrition, and behavioural intervention. |
|
| Control | No Intervention | standard usual care |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Multifaceted intervention | Behavioral | multifaceted family-based, physical exercise, nutrition, and behavioural intervention study for 18 month, in children aged 6-16 years with asthma and overweight/obesity. |
| Measure | Description | Time Frame |
|---|---|---|
| Forced Expiratory Volume in the first second (FEV1 %) predicted value | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Airway inflammation | 2 years | |
| Symptom-free days, exacerbations | 2 years | |
| Need for beta-2 agonists/anti-inflammatory medication |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Edward Dompeling, PhD, MD | Maastricht University Medical Centre | Principal Investigator |
| Kim van de Kant, MSc | Maastricht University Medical Centre | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maastricht University Medical Centre | Maastricht | Limburg | 6202 AZ | Netherlands | ||
| Maastricht University Medical Centre |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27294869 | Derived | Willeboordse M, van de Kant KDG, Tan FE, Mulkens S, Schellings J, Crijns Y, Ploeg Lv, van Schayck CP, Dompeling E. A Multifactorial Weight Reduction Programme for Children with Overweight and Asthma: A Randomized Controlled Trial. PLoS One. 2016 Jun 13;11(6):e0157158. doi: 10.1371/journal.pone.0157158. eCollection 2016. | |
| 23692648 |
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| ID | Term |
|---|---|
| D001249 | Asthma |
| D050177 | Overweight |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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|
| 2 years |
| Weight, height, body mass index (BMI) | 2 years |
| Levels of serum adipokines | 2 years |
| aerobic capacity | VO2max measured with an maximal ergometry test | 2 years |
| Maastricht |
| Limburg |
| 6202AZ |
| Netherlands |
| Willeboordse M, van de Kant KD, de Laat MN, van Schayck OC, Mulkens S, Dompeling E. Multifactorial intervention for children with asthma and overweight (Mikado): study design of a randomised controlled trial. BMC Public Health. 2013 May 21;13:494. doi: 10.1186/1471-2458-13-494. |
| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |