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| Name | Class |
|---|---|
| S. Anna Hospital | OTHER |
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This is a perspective multicentric study for the treatment of patients aged equal or less than 60 years and submitted to an allogeneic hematopoietic stem cell transplantation from an HLA compatible related or unrelated donor because affected by resistent or refractory or relapsed after autologous stem cell transplantation Ewing Sarcoma or Soft tissues sarcoma who did not benefit from conventional therapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stem Cell Transplant | Experimental | All the patient who are affected by refractory or resistant or relapsed Soft tissue sarcoma o Ewing sarcoma who find an HLA compatible allogeneic donor and are submitted to Stem cell transplantation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Allogeneic hemopoietic stem cell transplant | Procedure | administration of 15 mg/kg of thiotepa + 140 mg/sqm of melphalan followed by infusion of allogeneic hemopoietic stem cell |
|
| Measure | Description | Time Frame |
|---|---|---|
| Progression Free Survival (PFS) a 12 months from the enrollment higher than 30% for the patients submitted to allogeneic stem cell transplantation in front of the patients who received conventional chemotherapy. | 12 months from the enrollement |
| Measure | Description | Time Frame |
|---|---|---|
| Transplant related mortality | 12 months after the enrollement of the first patients |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Arcangelo Prete, MD, PhD, PI | S. Orsola-Malpighi Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pediatric Oncology and Hematology Department, S. Orsola-Malpighi Hospital | Bologna | 40138 | Italy |
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|
| ID | Term |
|---|---|
| D012509 | Sarcoma |
| ID | Term |
|---|---|
| D018204 | Neoplasms, Connective and Soft Tissue |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
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