The purpose of this study is to assess the safety and immune response of the rotavirus vaccine in infants who have undergone abdominal surgery.

Inclusion Criteria:

• Infants with one of the following diagnoses:

  • necrotizing enterocolitis requiring operation;
  • congenital atresia of the intestine;
  • gastroschisis;
  • midgut volvulus requiring bowel resection; or
  • long-segment intestinal aganglionosis

• Minimum gestational age of 35 weeks at time of first vaccine dose

Exclusion Criteria:

• immunocompromise secondary to HIV infection or immunodeficiency state
• active use of corticosteroid or other immunosuppressive agents
• active infection as defined by fever > 38°C within 24 hours, positive blood culture within 7 days, or positive urine culture within 3 days of enrollment
• severe malnutrition as defined by serum albumin < 2.0 mg/dL or serum prealbumin < 6 mg/dL.