Tranexamic Acid in Pediatric Cardiac Surgery

Tranexamic Acid Reduces Blood Loss in Pediatric Cardiac Surgery

Tranexamic acid(TXA) is an antifibrinolytic agent to reduce blood loss in cardiac surgery. Previous seven RCTs comparing effects of TXA in pediatric cardiac surgery showed conflict results. The reason why they showed mixed results would be the imbalance of patients population with regard to presence of cyanosis. TXA would reduce blood loss in pediatric cardiac surgery with well balanced patients population.

Inclusion Criteria:

• children undergoing elective cardiac surgery with cardiopulmonary bypass

Exclusion Criteria:

• neonate born within 1 month
• preoperative inotropes
• preoperative mechanical ventilation
• preexisting coagulation disorder
• reoperation within 48 hours
• significant liver or kidney disease
• known allergy to TXA