Plaque Registration and Event Detection In Computed Tomography

Prospective Multicenter Study to Investigate the Relationship Between the Characteristics of Coronary Artery Plaques and Cardiovascular Events Using Multidetector Computed Tomography Coronary Angiography

Disruption of an atherosclerotic plaque is responsible for at least two-thirds of acute coronary syndrome. Thus, identification of plaques vulnerable to rupture has become important. The natural history of individual plaques is unknown and needs to be established. Multidetector computed tomography (MDCT) angiography is a useful noninvasive imaging modality for assessing coronary plaque characteristics. Using MDCT, the researchers prospectively investigate the relationship between the characterization of coronary plaques and cardiovascular events in a large multicenter study.

Inclusion Criteria:

• patients with known or suspected coronary artery disease.

Exclusion Criteria:

• irregular heart beat,
• known allergy towards the contrast agent,
• renal dysfunction,
• uncontrolled heart failure,
• previous coronary bypass surgery, or pacemaker or ICD implantation, ST elevation MI or unstable hemodynamic condition,
• impossible breath-hold, OR
• end-stage cancer.