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| Name | Class |
|---|---|
| Ministere de la Sante et des Services Sociaux | OTHER |
| Novonordisk endocrine fellowship program | UNKNOWN |
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This study compared the efficacy at one year of an interdisciplinary approach including individual counseling and group seminars versus group seminars alone to induce weight loss in subjects at high risk of developing type 2 diabetes.
This study also compare if a participant's presence in small informative meeting groups as the only form of intervention is sufficient to induce a lifestyle change, thus inducing the weight loss needed for the prevention of the diseases associated with obesity.
Eligible participants will be randomized into 2 intervention groups (30 per group):
Subjects will be evaluated initially and then every 3 months during 1 year by the following measurements: questionnaires to evaluate motivation and physical activity; 3 day dietary journals; weight assessment, using both metabolic and mechanical balance; waist circumference; and blood pressure.
A medical evaluation with size measure, a test evaluating knowledge of the participants on obesity, OGTT (Oral Glucose Tolerance Test) - a 5 hour determination of secretion and resistance to insulin, insulin-mediated suppression of plasma non-esterified fatty acids, a plasma lipid profile, accelerometry, bio electric impedance, and an activity physical test (6 minute walk test) will be carried out initially, and then repeated for up to 1 year.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | interdisciplinary weight loss intervention |
|
| 2 | Active Comparator | Small group seminars without interdisciplinary intervention |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| interdisciplinary intervention or meeting-seminars | Behavioral | one-year individualized interdisciplinary weight loss program vs. small group seminars on healthy lifestyle |
|
| Measure | Description | Time Frame |
|---|---|---|
| a weight loss of 7% in at least 19% of the subjects | one year | |
| reduced body weight of at least 5.6 kg in at least 25% of the subjects | one year | |
| an increase in the level of physical activity by at least 150 minutes per week in at least 29% of the subjects | one year | |
| a reduced daily caloric intake of at least 450 kcal/jour in at least 25% of the subjects | one year | |
| a reduced percentage of the calories introduced in the form of fat of at least 6.6%, in absolute value, in at least 25% of the subjects | one year |
| Measure | Description | Time Frame |
|---|---|---|
| change in insulin sensitivity by HOMA | one year | |
| change in insulin secretion during an OGTT by deconvolution of plasma c-peptide | one year | |
| change in beta cell function by calculation of the disposition index |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Marie-France Langlois, MD | Medecine department, Division of endocrinology, CHUS | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre de Recherche Clinique (CRC), Centre Hospitalier Universitaire de Sherbrooke | Sherbrooke | Quebec | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21489843 | Derived | Gagnon C, Brown C, Couture C, Kamga-Ngande CN, Hivert MF, Baillargeon JP, Carpentier AC, Langlois MF. A cost-effective moderate-intensity interdisciplinary weight-management programme for individuals with prediabetes. Diabetes Metab. 2011 Nov;37(5):410-8. doi: 10.1016/j.diabet.2011.01.003. Epub 2011 Apr 13. |
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| ID | Term |
|---|---|
| D050177 | Overweight |
| D018149 | Glucose Intolerance |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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| one year |
| change in insulin-mediated suppression of plasma non-esterified fatty acids during an OGTT | one year |
| relation between weight loss and change in insulin sensitivity, beta cell function, and insulin-mediated suppression of plasma non-esterified fatty acids | one year |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006943 | Hyperglycemia |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |