To Compare Positron Emission Tomography (PET) Measurements of Fibrillar Amyloid Burden

A Phase II, Open Label, Non-Randomized Study of [18F]AZD4694 to Compare PET Measurements of Fibrillar Amyloid Burden Obtained Using Difference Scanning Parameters, Reference Region Procedures and to Assess Test-retest Reliability in Patients With AD & HV

The purpose of this study is to compare PET measurements of fibrillar amyloid burden using [18F]AZD4694.

Inclusion Criteria:

• Male or female, of any race or/ethnicity
• ECG, vital signs, and clinical laboratory values are within normal limits at enrollment or deemed not clinically significant by the physician

Exclusion Criteria:

• Significant recent (within 6 months) history of neurological (including stroke) or psychiatric disorder or substance abuse
• Participated in a PET study within the last 12 months
• Pregnancy or lactation